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IL13 — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → IL13 (increases) Kawaguchi et al., J Allergy Clin Immunol 2001*
  Evidence: Stimulation of the cells with each of the 3 cytokines IL-17, IL-4, and IL-13 induces the expression of both IL-6 and IL-8 (Fig 4), and among all 4 cytokines IL-17 is the most potent inducer. However, IL-17 alone did not induce ICAM-1 expression, which is in contrast to the finding of a significant induction of ICAM-1 expression by 3 other cytokines (Fig 4).

Text-mined interactions from Literome

Shinoda et al., Cell Signal 1999 : C2-ceramide did not affect the IL-6 synthesis induced by interleukin-1
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : In addition, interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and interleukin-6 , with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Lee et al., Arch Pharm Res 2000 : High level of macrophage-colony stimulating factor ( M-CSF ) and interleukin (IL)-6 was detected in the TFGD-culture supernatant, whereas granulocyte/macrophage-colony stimulating factor ( GM-CSF ), IL-3, IL-4, IL-5, IL-13 , or interferon (IFN)-gamma was undetectable
Frost et al., Bone 2001 : Interleukin (IL)-13 and IL-4 inhibit proliferation and stimulate IL-6 formation in human osteoblasts : evidence for involvement of receptor subunits IL-13R, IL-13Ralpha, and IL-4Ralpha ... IL-4 and IL-13 dose-dependently inhibited [ ( 3 ) H ] -thymidine incorporation into the DNA of human osteoblasts and stimulated secretion of IL-6 into culture supernatants ... IL-13 and IL-4 also increased the mRNA levels of IL-6 , as measured by RNAse protection assay ... Receptor blocking antibodies to IL-4Ralpha inhibited the induction of IL-6 formation by both IL-4 and IL-13 , indicating that both cytokines utilize this receptor subunit in signaling
Ishikawa et al., Jpn J Vet Res 2001 : Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Kovár et al., Parasitol Res 2002 : ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE enhanced interleukin (IL)-1alpha, IL-1beta, IL-1Ra, IL-6 , and IL-12p40 cytokines, whereas production of IL-2, IL-5, IL-10, and IL-13 was decreased
Huang et al., Am J Respir Cell Mol Biol 2003 : The increases in IL-6 protein and total mRNA were inhibited by the selective B ( 2 ) receptor antagonist HOE-140 but not by the selective B ( 1 ) receptor antagonist desArg ( 9 ) ( Leu ( 8 ) ) -BK. Actinomycin D ( a transcription inhibitor ), dexamethasone, indomethacin, IL-4, and IL-13 ( Th ( 2 ) type cytokines ) inhibited the expression of IL-6 by BK
Nasu et al., Fertil Steril 2003 : The effects of IL-13 and TNF-beta, on the production of IL-6 , IL-11, leukemia inhibitory factor (LIF), IL-8, growth regulated oncogene alpha ( GROalpha ), monocyte chemoattractant protein-1 ( MCP-1 ), regulated on activation, T-cell expressed and secreted ( RANTES ), and eotaxin were investigated
Yamamoto et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : The effects of RasDN overexpression on cellular proliferation, interleukin-1 (IL-1) induced activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and IL-6 production by synovial cells were analyzed
Planck et al., Invest Ophthalmol Vis Sci 1992 : Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1
Shimizu et al., Arch Oral Biol 1992 : Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells
Wongpiyabovorn et al., J Dermatol Sci 2003 (Dermatitis, Atopic...) : Furthermore, the stimulation of HPK with IFN-gamma plus IL-13 and/or IL-4 resulted in significant enhancement of IL-6 and RANTES secretion
Nishitai et al., J Biol Chem 2004 : Instead, interleukin-1 beta (IL-1 beta) induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Saito et al., Mech Ageing Dev 2003 (Endotoxemia...) : The stress mediated induction of interleukin-1beta, interleukin-6 , and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of IL-6 was significantly augmented with aging
Silfverswärd et al., J Orthop Res 2004 : Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells
Nesbitt et al., Mol Biol Cell 1992 (Inflammation) : We employed ribonuclease protection assays to measure the expression of IL-6-R and gp130 mRNA in primary rat hepatocytes in response to IL-6, interleukin-1 , dexamethasone, and combinations thereof
Melk et al., Transplantation 2004 (Growth Disorders...) : During rhGH therapy in children with transplants, interleukin (IL)-2 production increased threefold at 4 weeks, and IL-4 and IL-13 increased by 70 % at 12 weeks
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6 , transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Bouchelouche et al., J Urol 2006 : We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13 , IL-1beta and tumor necrosis factor-alpha ... IL-4 and IL-13 given separately stimulated MCP-1, IL-6 and SCF secretion in a concentration ( 0.01 to 100 ng/ml ) and time ( 0 to 24 hours ) dependent manner
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Szabo et al., J Clin Immunol 1991 (Burns...) : Furthermore, interleukin-4 dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels
Burch et al., Agents Actions 1991 (Wounds and Injuries) : Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced interleukin-1 stimulated interleukin-6 release from fibroblasts
Chen et al., Zhonghua Jie He He Hu Xi Za Zhi 2007 : The inhibitory effect of BDP or BUD on IL-13 induced IL-6 and eotaxin release in fibroblast may contribute to the attenuation of IL-13 induced subepithelial fibrosis
Krogh Rasmussen et al., Acta Endocrinol (Copenh) 1991 : In conclusion, it is unlikely that interleukin 6 by itself mediates the biological effects of interleukin 1 on human thyroid cells
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Hammer et al., Microbiol Immunol 2008 : Oil B inhibited the production of all cytokines except IL-10, oil X inhibited TNF-alpha, IL-6 and IL-10, oil A inhibited TNF-alpha and IL-6, oil C inhibited IL-5 and IL-6 and oil Z inhibited IL-13 only
Baigrie et al., Lymphokine Cytokine Res 1991 (Aortic Aneurysm...) : A sequential interleukin-1 beta and interleukin-6 response has not been noted before in vivo, and would seem to provide evidence supporting the in vitro observation that interleukin-1 induces interleukin-6 synthesis and release
Braquet et al., Int Arch Allergy Appl Immunol 1991 : We compared the effects of platelet activating factor (PAF), interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on IL-6 production by confluent L929 mouse fibroblasts
Zhang et al., Cytokine 2010 : The results showed that IL-6 induced up to 1.8-fold increase in IL-13, but not IL-4 or IL-10 release from P815 cells, and FSLLRY-NH ( 2 ) did not affect IL-6 induced IL-13 release ... U0126, PD98059 and LY204002 abolished IL-6 induced IL-13 release when they were preincubated with P815 cells, indicating ERK and Akt cell signaling pathways may be involved in the event ... In conclusion, IL-6 can stimulate IL-13 release from mast cells through an ERK and Akt cell signaling pathway dependent, but PAR independent mechanism
Zhang et al., Beijing Da Xue Xue Bao 2010 (Chlamydia Infections...) : [ Early production of interleukin-17 in airway upon Chlamydia trachomatis infection increases the local secretion of IL-6 and MIP-2 ]
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : Grape seed proanthocyanidin extract inhibits interleukin-17 induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells
Tanabe et al., Journal of neuroinflammation 2011 : Midazolam suppresses interleukin-1ß induced interleukin-6 release from rat glial cells
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Involvement of angiotensin II type 1 receptors in interleukin-1ß induced interleukin-6 production in human gingival fibroblasts
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
Libert et al., Eur J Immunol 1990 : Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Kuroyanagi et al., Biochimie 2013 : ( - ) -Epigallocatechin gallate amplifies interleukin-1 stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells
Bunning et al., Biochem Biophys Res Commun 1990 : Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo
Helle et al., Eur J Immunol 1988 : Interleukin 6 is involved in interleukin 1-induced activities
Zimecki et al., Arch Immunol Ther Exp (Warsz) 1994 : Interleukin 6 produced by activated thymocytes induces interleukin 1 production by macrophages
Punnonen et al., J Immunol 1994 : IL-13- and IL-4 induced IgE synthesis by s mu+, CD19+ fetal B cells was enhanced by IL-6 and inhibited by IL-12, IFN-alpha, IFN-gamma, and transforming growth factor-beta, suggesting that IL-13 and IL-4 induce IgE synthesis via similar signaling pathways
Cadman et al., Neurosci Lett 1994 (Astrocytoma) : cAMP is not involved in interleukin-1 induced interleukin-6 release from human astrocytoma cells
Carlson et al., J Neurochem 1995 (Astrocytoma) : Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1 induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C ... We conclude that tyrosine kinase activity is essential for interleukin-1 induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved
Zitnik et al., Am J Physiol 1993 : cAMP inhibition of interleukin-1 induced interleukin-6 production by human lung fibroblasts
Bouteiller et al., J Immunol Methods 1995 : Although the B9-1-3 cell line is still sensitive to picogrammes of IL-6, it can be used to measure IL-13 in the presence of IL-6 by inclusion of excess neutralizing IL-6 antibody
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha, interleukin-1-beta , and cholera toxin all stimulated IL-6 secretion
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF, and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
de Waal Malefyt et al., J Immunol 1993 : Furthermore, IL-13 inhibited production of IL-1 alpha, IL-1 beta, IL-6 , IL-8, IL-10, IL-12 p35, IL-12 p40, macrophage inflammatory protein-1 alpha, granulocyte/macrophage-CSF, granulocyte-CSF, IFN-alpha, and TNF alpha by monocytes activated with LPS
Derocq et al., FEBS Lett 1994 : Interleukin-13 stimulates interleukin-6 production by human keratinocytes ... IL-13 , similarly to IL-4, stimulated IL-6 expression by these cells in a dose- and time dependent manner ... Further, we showed that IL-13 , like IL-4, not only stimulated IL-6 production but also was able to induce overexpression of this cytokine in response to an inflammatory signal such as lipopolysaccharide (LPS)
Mikovits et al., J Leukoc Biol 1994 : In the presence of tumor necrosis factor alpha or IL-6 , which upregulate HIV expression, IL-13 could no longer suppress HIV expression
Ng et al., J Biol Chem 1994 : Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1
Moutabarrik et al., Scand J Immunol 1994 : IL-6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Ueo et al., J Am Coll Surg 1994 : The IL-6 secretion by skin explants was significantly enhanced either by tumor necrosis factor or interleukin-1 , while it was inhibited by corticosteroids
Utsunomiya et al., Eur J Pharmacol 1994 (Pleurisy) : However, production of tumor necrosis factor (TNF) and interleukin-1 in the pleural exudate was significantly enhanced by the pretreatment with indomethacin, whereas the interleukin-6 level was reduced
Levine et al., Psychoneuroendocrinology 1994 : Pituitary-adrenal and interleukin-6 responses to recombinant interleukin-1 in neonatal rats
Boxman et al., J Invest Dermatol 1993 : The remaining interleukin-1 activity, however, was sufficient for maximal induction of interleukin-6 production in fibroblasts
de Fijter et al., Am J Kidney Dis 1996 : In addition, interleukin-1-beta induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Bruserud et al., Leukemia 1996 (Leukemia, Myeloid, Acute) : In contrast, IL-13 inhibited constitutive AML blast secretion of IL-1 alpha, IL-1 beta, IL-6 , tumor necrosis factor alpha, granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor
Kimata et al., J Exp Med 1996 : In sIgE-sIgG4- B cells, IL-4 plus anti-CD58 mAb induced IL-10 production and IL-10 receptor expression, whereas IL-13 plus anti-CD58 mAb induced IL-6 production and IL-6 receptor expression ... Histamine increased IL-10 and IL-6 production without affecting IL-10 and IL-6 receptor expression, in cultures with IL-4 plus anti-CD58 mAb and with IL-13 plus anti-CD58 mAb, respectively, which was blocked by thioperamide and dimaprit, respectively
Topley et al., J Am Soc Nephrol 1996 : Similarly, interleukin (IL)-1 beta induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Sébire et al., Cytokine 1996 : The effect of interleukin 4 (IL-4) and IL-13 on IL-6 and IL-1 beta production by human embryonic microglial cells and human peripheral blood monocyte cells ( PBMC ) was compared
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Hedges et al., Cytokine 1996 : IL-4, IL-13 , IFN-gamma, and TGF-beta 1, but not IL-2, IL-5, IL-10 or IL-12, stimulated IL-6 secretion ... IL-5, IL-12, IL-13 and TGF-beta 1 additively enhanced the bacterially induced IL-6 secretion, but they did not affect IL-8 secretion
Kucharzik et al., Clin Exp Immunol 1996 (Colitis, Ulcerative...) : The inhibitory effect of IL-13 on TNF-alpha and IL-6 production in differentiated macrophages was diminished in IBD patients, as well as in controls
Meyer et al., Clin Sci (Lond) 1997 (Endotoxemia...) : 3. Administration of endotoxin induced a greater than fourfold increase in brain interleukin-1 , a greater than threefold increase in interleukin-6 and an increase in mRNA for both cytokines
Jones et al., J Pathol 1997 (Meningioma) : Effect of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas
Porro et al., J Pharmacol Exp Ther 1998 (Shock, Septic) : In vitro experiments showed that ITF1779 inhibited not only huTNFalpha induced cytotoxicity on LM cells but also another response of the same cells, interleukin-1 induced interleukin-6 production
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998 : However, retinoic acid had little effect on the IL-6 synthesis induced by interleukin-1
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Frost et al., J Clin Endocrinol Metab 1998 (Osteosarcoma) : Interleukin-13 inhibits cell proliferation and stimulates interleukin-6 formation in isolated human osteoblasts ... Also, IL-13 increased the levels of IL-6 messenger ribonucleic acid in hOBs, as measured by ribonuclease protection assay, and stimulated secretion of IL-6 into culture supernatants ... In conclusion, IL-13 inhibits cell proliferation and increases IL-6 formation in human osteoblasts
Keelan et al., Am J Reprod Immunol 1998 : Basal IL-6 production was stimulated approximately twofold by IL-4 and IL-13 , whereas IL-4 and IL-13 both inhibited cytokine stimulated ( but not basal ) IL-8 production by approximately 50 %