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INS — POLDIP2
Text-mined interactions from Literome
Igarashi et al., Eur J Clin Invest 2000
(MAP Kinase Signaling System) :
In this study, we investigated the
effect of
insulin on
p38 mitogen activated protein ( MAP ) kinase activation in cultured rat vascular smooth muscle cells ( VSMC )
Somwar et al., Diabetes 2000
:
The stress activated
p38 mitogen activated protein kinase ( MAPK ) was recently shown to be
activated by
insulin in muscle and adipose cells in culture
Byon et al., Mol Cell Biochem 2001
:
In conclusion, induction of MKP-1 mRNA expression in Hirc B cells by
insulin requires activation of both the ERK and JNK pathways, but not
p38MAPK
Thong et al., J Appl Physiol 2003
:
Prior exercise increases basal and
insulin induced
p38 mitogen activated protein kinase phosphorylation in human skeletal muscle ... We have examined the
effects of
insulin on
p38 mitogen activated protein kinase ( MAPK ) phosphorylation in human skeletal muscle and the effects of prior exercise hereon ...
Insulin induced a modest sustained 1.2- and 1.3-fold increase ( P < 0.05 ) in
p38 MAPK phosphorylation in the rested and exercised legs, respectively
Koistinen et al., Diabetologia 2003
(Diabetes Mellitus, Type 2) :
In vitro
effects of
insulin ( 120 nmol/l ) or AICAR ( 1 mmol/l ) on
p38 MAPK expression and phosphorylation were determined in skeletal muscle from non-diabetic ( n=6 ) and Type 2 diabetic ( n=9 ) subjects
Perdomo et al., J Biol Chem 2004
(Insulin Resistance) :
Two to 3-fold overexpression of L-CPT I, the endogenous isoform in L6 cells, proportionally increased oxidation of the long-chain fatty acids palmitate and oleate and increased insulin stimulation of [ ( 14 ) C ] glucose incorporation into glycogen by 60 % while enhancing
insulin stimulated phosphorylation of
p38MAPK
Carlson et al., Metabolism 2005
(Insulin Resistance) :
However,
p38 inhibition did not
prevent the loss of IRS-1 protein levels or
insulin signaling to PKB in insulin-resistant cells
Pelletier et al., Mol Cell Biochem 2007
:
Although
insulin did not significantly
stimulate p38MAPK phosphorylation, vanadate increased it by 3.8-fold
Morisco et al., Cardiovasc Res 2007
(Insulin Resistance) :
Insulin inhibited hypoxia induced phosphorylation of
p38 through MAPK phosphatase-1 (MKP-1)
Zheng et al., Arch Med Res 2008
(Atherosclerosis) :
Se also inhibited high glucose- and high
insulin induced activation of
p38 mitogen activated protein kinase ( p38 ), which indicated that the preventive effects of Se on adhesion molecules may be associated with p38
Hemi et al., Diabetes 2011
(Insulin Resistance) :
Liver expression of dominant negative ( DN )
-p38MAPKa in ob/ob mice
reduced fasting
insulin levels and improved glucose tolerance, whereas C57/BL6 mice overexpressing wild-type p38MAPKa exhibited enhanced IRS-1 serine phosphorylation and reduced insulin stimulated IRS-1 tyrosine phosphorylation
Guo et al., J Biol Chem 1998
(Insulin Resistance) :
Insulin , like expression of Q205L Galphai2,
activates both
p38 and c-Jun N-terminal kinases as well as glycogen synthase