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MAPK14 — NCF1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Circulation 2004
(MAP Kinase Signaling System) :
Opposing
roles of
p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and
mitogen activated protein kinase activation
Pacquelet et al., Biochem J 2007
:
LPS dependent phosphorylation of
p47phox was
enhanced by the inhibition of p38
MAPK ( mitogen activated protein kinase ), confirming that the kinase operates upstream of p38 MAPK
Qian et al., EMBO J 2009
:
The p38
MAPK inhibitor, SB203580, significantly
reduced p47(phox) phosphorylation and diminished superoxide production in neutrophils
Lu et al., Clin Exp Immunol 2010
(MAP Kinase Signaling System) :
Therefore, ketamine racemes
inhibited fMLP induced superoxide anion generation and
p47(phox) phosphorylation by modulating fMLP mediated p38
MAPK activation in neutrophils
Kim et al., Apoptosis 2011
:
JNK and p38
MAPK play a key role in activation of NADPH oxidase, since inhibition of their expression or activity abrogated membrane translocation of
p47(phox) and p67(phox) subunits and ROS generation