◀ Back to NOTCH1

MMP9 — NOTCH1

Text-mined interactions from Literome

Wang et al., Cancer Res 2006 (Neoplasm Invasiveness...) : Because NF-kappaB, VEGF, and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role and mechanism ( s ) by which Notch-1 down-regulation ( using molecular approaches ) may lead to the down-regulation of NF-kappaB, vascular endothelial growth factor ( VEGF ), and MMP-9 , thereby inhibiting invasion of pancreatic cancer cells through Matrigel
Bin Hafeez et al., Clin Cancer Res 2009 (Adenocarcinoma...) : A significant reduction in MMP9 expression in Notch1 knockdown cells suggested a role for Notch1 in augmenting MMP9 transcription
Bansal et al., PloS one 2009 : PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling ... Enforced expression of the cleaved Notch1 in macrophages induces the expression of COX-2 and MMP-9
Funahashi et al., Vascular cell 2011 : In a murine model of VEGF induced dermal angiogenesis, Notch inhibition led to reduced MMP9 expression
Garg et al., Gastroenterology 2011 (Colitis...) : Epithelial cell derived matrix metalloproteinase (MMP)-9 mediates inflammation during acute colitis and the cleavage and activation of the transcription factor Notch1 , which prevents differentiation of progenitor cells into goblet cells ... MMP-9 mediates Notch1 signaling via p53 to regulate apoptosis, cell cycle arrest, and inflammation
Zou et al., Journal of hematology & oncology 2013 (Neoplasm Invasiveness...) : Hypoxia induced Notch1 activation increased the expression of matrix metalloproteinase-2 (MMP2) and MMP9 , which increased invasiveness
Hindi et al., PloS one 2013 : Moreover, inhibition of MMP-9 increases the expression of Notch ligands and receptors, and Notch target genes in skeletal muscle of mdx mice