◀ Back to SREBF1

SP1 — SREBF1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → SREBF1 (transcriptional regulation, unknown)
  Evidence: DNABINDING
• Reactome Reaction: SP1 → SREBF1 (indirect_complex) Xiong et al., Proc Natl Acad Sci U S A 2000*, Amemiya-Kudo et al., J Lipid Res 2002*, Oh et al., J Biol Chem 2003*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Bennett et al., J Biol Chem 1995*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
• Reactome Reaction: SP1 → SREBF1 (reaction) Xiong et al., Proc Natl Acad Sci U S A 2000*, Amemiya-Kudo et al., J Lipid Res 2002*, Oh et al., J Biol Chem 2003*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Bennett et al., J Biol Chem 1995*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SP1 — SREBF1 (direct interaction, pull down) Bennett et al., J Biol Chem 1999*
• IRef Biogrid Interaction: SP1 — SREBF1 (association, biochemical) Näär et al., Nature 1999
• IRef Hprd Interaction: SREBF1 — SP1 (in vitro) Bennett et al., J Biol Chem 1999*
• IRef Ophid Interaction: SREBF1 — SP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SREBF1 — SP1 (aggregation, confirmational text mining) Bennett et al., J Biol Chem 1999*

Text-mined interactions from Literome

Deng et al., J Biol Chem 2007 : These studies identify a novel mechanism by which maximal activation of the rat SREBP-1c gene expression by insulin is mediated by Sp1 and its enhanced ability to interact with other transcriptional regulatory proteins
Damiano et al., Biochem J 2009 : Our data show that PUFA inhibition of hepatic Cic gene transcription is mediated not only by the nuclear level of SREBP-1c , but also might involve a reduction in Sp1 and NF-Y DNA binding, suggesting differential mechanisms in the Cic gene regulation by different PUFA
Yamamoto et al., J Lipid Res 2010 (Diabetes Mellitus, Experimental) : Knockdown of Sp proteins demonstrated that Sp3 and Sp1 play reciprocally negative and positive roles in nutritional regulation of SREBP-1c , respectively
Deng et al., J Biol Chem 2012 : CA-FoxO1 inhibited SREBP-1c by reducing the transactivational capacity of both Sp1 and SREBP-1c