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CCK — PXN

Text-mined interactions from Literome

Garcia et al., Biochim Biophys Acta 1997 : CCK causes rapid tyrosine phosphorylation of p125FAK focal adhesion kinase and paxillin in rat pancreatic acini
García et al., Biochem J 1997 : Cholecystokinin stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho ... CCK-8 stimulated phosphorylation of p125(FAK) and paxillin reached a maximum within 2.5 min ... Treatment with Clostridium botulinum C3 transferase, which inactivates p21 ( rho ), caused significant inhibition of CCK-8 stimulated p125(FAK) and paxillin phosphorylation
Lutz et al., Am J Physiol 1997 : We propose that paxillin might be involved in CCK-but not in VIP induced exocytosis
Rosado et al., Biochim Biophys Acta 1998 : Pretreatment with genistein, a tyrosine kinase inhibitor, decreased CCK-8 stimulated tyrosine phosphorylation of p125FAK and paxillin and CCK-8 stimulated amylase secretion by more than 60 %, raising the possibility that tyrosine phosphorylation of these two proteins could be important in the ability of CCK-8 to stimulate amylase release ... Pretreatment with different concentrations of cytochalasin D, an actin cytoskeleton assembly inhibitor, completely inhibited CCK-8 stimulated tyrosine phosphorylation of p125FAK and paxillin without having any effect on either the potency or efficacy of CCK-8 at stimulating amylase release ... However, our results suggest Rho is involved in the CCK-8 stimulation of amylase release by a parallel pathway to its involvement in the CCK-8 stimulated tyrosine phosphorylation of p125FAK and paxillin