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DISC1 — EGFR
Text-mined interactions from Literome
Reinehr et al., FASEB J 2003
:
Inhibition of
EGFR tyrosine kinase activity
prevented CD95 tyrosine phosphorylation and
DISC formation but not hyperosmolarity induced EGFR phosphorylation and EGFR association with CD95
Eberle et al., Hepatology 2005
:
Inhibition of
EGFR tyrosine kinase activity by AG1478 and cyclic adenosine monophosphate had no effect on hyperosmotic CD95-EGFR association in the cytosol but
prevented CD95 tyrosine phosphorylation, targeting of the protein complex to the plasma membrane, and formation of the death inducing signaling complex (
DISC )
Xu et al., Eur J Cancer 2012
(Stomach Neoplasms) :
The contribution of
DISC formation and the
inhibition of
EGFR signal triggered in lipid rafts are both essential for increasing the sensitivity of gastric cancer cells to TRAIL