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ANXA6 — TP53

Text-mined interactions from Literome

Bates et al., EMBO J 2005 : Strikingly, RNAi suppression of p68 inhibits p53 target gene expression in response to DNA damage, as well as p53 dependent apoptosis, but does not influence p53 stabilisation or expression of non-p53-responsive genes ... We also show, by chromatin immunoprecipitation, that p68 is recruited to the p21 promoter in a p53 dependent manner, consistent with a role in promoting transcriptional initiation
Moore et al., Oncogene 2010 (Breast Neoplasms) : Consistent with these findings, small interfering RNA depletion of p68 in cell lines results in a p53-dependant increase of d133p53 in response to DNA damage, suggesting that increased d133p53 expression could result from downregulation of p68 and provide a potential mechanistic explanation for our observations in breast cancer