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HSP90AB1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TP53 — HSP90AB1 (in vitro) King et al., EMBO J 2001*
• IRef Hprd Interaction: TP53 — HSP90AB1 (in vivo) King et al., EMBO J 2001*
• IRef Intact Interaction: TP53 — HSP90AB1 (physical association, luminescence based mammalian interactome mapping) Taipale et al., Cell 2012
• IRef Ophid Interaction: TP53 — HSP90AB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TP53 — HSP90AB1 (aggregation, confirmational text mining) King et al., EMBO J 2001*
• STRING interaction: TP53 — HSP90AB1 (interaction, mapped from bind)
• STRING interaction: HSP90AB1 — TP53 (interaction, mapped from kegg_pathways intact dip)

Text-mined interactions from Literome

Peng et al., J Biol Chem 2001 : These results suggest that hsp90 recruited by mutant p53 conceals the ARF binding site on MDM2 and inhibits its ubiquitin-protein isopeptide ligase function, resulting in the stabilization of both mutant p53 and MDM2
Asher et al., Proc Natl Acad Sci U S A 2002 : Differences in the effectiveness of dicoumarol and hsp90 inhibitors to induce p53 degradation and suppress apoptosis in these cell types indicate that NQO1 and hsp90 stabilize p53 through different mechanisms
Wang et al., J Biol Chem 2003 : Inhibition of hsp90-p53 interaction by geldanamycin prevented p53 accumulation partially in ATM-wild type cells and completely in ATM-deficient cells
Dasgupta et al., Exp Cell Res 1997 : The present study was undertaken to determine the p53 conformation bound to hsp90 and the role of hsp90 in p53 nuclear translocation