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CXCL2 — PTGS2

Text-mined interactions from Literome

Põld et al., Cancer Res 2004 (Carcinoma, Non-Small-Cell Lung...) : Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer ... To elucidate the role of COX-2 in the in vitro and in vivo expression of two known NSCLC angiogenic peptides, CXC ligand ( CXCL ) 8 and CXCL5, we studied two COX-2 gene modified NSCLC cell lines, A549 and H157 ... COX-2 overexpression enhanced the in vitro expression of both CXCL8 and CXCL5
Hamada et al., J Immunol 2008 (Reperfusion Injury) : The lack of COX-2 expression resulted in decreased levels of CXCL2 , a neutrophil activating chemokine, reduced infiltration of MMP-9 positive neutrophils, and impaired late macrophage activation in livers after I/R injury
Brant et al., Toxicological sciences : an official journal of the Society of Toxicology 2009 : Consistent with our previous findings that Ni and MALP-2 stimulates the induction of CXCL8 via a COX-2 mediated pathway, CXCL1 , CXCL5, and VEGF release were also regulated by COX-2