We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to CD4

CD4 — IL5

Text-mined interactions from Literome

Richards et al., Eur J Immunol 2000 : Glucocorticoids are highly effective in the treatment of allergy and asthma and inhibit the synthesis of IL-4, IL-5 and IL-13 by disease promoting CD4 ( + ) Th2 cells
Matsumoto et al., Int Arch Allergy Immunol 2003 (Eosinophilia...) : We examined the role of IL-5 in CD4+ T cell activation, cytokine production, and AHR upon Asc sensitization
Soldan et al., J Immunol 2003 (Multiple Sclerosis, Chronic Progressive...) : The increase in IL-5 was primarily due to an increase in CD4 ( + ) and CD8 ( + ) T cells, the increase in IL-10 was primarily due to an increase in CD64 ( + ) monocytes/macrophages with some effect in T cells, while the decrease in TNF-alpha was primarily due to a decrease in CD8 ( + ) T cells
Chihara et al., Eur Cytokine Netw 1992 : Induction of CD23, CD25 and CD4 expression on an eosinophilic cell line ( EoL-3 ) by interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ) and interleukin-5 (IL-5) ... The effects of IL-3, GM-CSF and IL-5 on the expression of CD23 ( Fc epsilon RII ), CD25 ( IL-2R/p55 ) and CD4 on an eosinophilic cell line ( EoL-3 ) were investigated by flow cytometry
Pepe et al., Curr Pharm Des 2006 : This Th1 polarizing activity is mediated by interleukin-12 released by infected CDs in the presence of CD4 ( + ) cells
Wells et al., J Allergy Clin Immunol 2007 (Inflammation...) : Adoptive transfer of transgenic antigen-specific CD8, but not CD4 , cells resulted in increased IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Ariga et al., Immunology 2007 : Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive CD4 ( + ) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Leech et al., J Immunol 2007 (Asthma...) : Most convincingly, transfer of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from Ag naive mice ( natural Tregs ) abolished AAI, decreased dMLN IL-5 and IL-13 secretion, increased dMLN IL-10 secretion, abolished IgE, and decreased IgG1 Abs. Blocking IL-10 receptor function in vivo did not block the anti-inflammatory function of transferred natural Tregs but did restore dMLN IL-5 and IL-13 secretion
Verma et al., Blood 2009 : CD4 ( + ) CD25 ( + ) T cells from tolerant hosts given IL-2 cultured cells had increased Il-5 and Ifngammar mRNA
Reyes et al., Am J Transplant 2013 (Conjunctivitis, Allergic...) : Exogenous IL-4, but not IL-5 or IL-13, prevented Treg suppression of CD4 ( + ) effector T cells isolated from naïve mice
Vandergeeten et al., Blood 2013 (HIV Infections) : When administered to HIV infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4 ( + ) T cells by promoting their survival and proliferation
Takamoto et al., Immunology 1995 (Toxocariasis) : Production of IL-5 was reduced by in vivo depletion of CD4+ cells only and both CD4+ and CD8+ T cells, by intraperitoneal injection with appropriate mAb ; IL-5 production was stimulated by anti-CD3 mAb
Chihara et al., Nihon rinsho. Japanese journal of clinical medicine 1993 : The effects of IL-3, GM-CSF and IL-5 on the expression of CD23 ( Fc ( E ) RII ), CD25 ( IL-2R/p55 ) and CD4 on an eosinophilic cell line ( EoL-3 ) were investigated by flow cytometry
Simeonovic et al., J Immunol 1997 (Neovascularization, Pathologic) : We previously identified CD4 T cell dependent enhancement of intragraft IL-3, IL-4, and IL-5 mRNA expression during acute xeno-rejection in CBA/H recipient mice
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively