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CA9 — SETD2
Text-mined interactions from Literome
Hoskin et al., Br J Cancer 2003
(Anoxia...) :
Glucose transporter-1 protein (GLUT1) and
carbonic anhydrase IX (CAIX) are
regulated by
hypoxia inducible factor-1 (HIF-1) and have been studied as putative intrinsic cellular markers for hypoxia
Kaluzová et al., Mol Cell Biol 2004
(Anoxia) :
In summary, our results demonstrate that the presence of wtp53 under hypoxic conditions has an insignificant effect on the stabilization of HIF-1alpha protein and
HIF-1 dependent expression of
CAIX
Ibrahim et al., Cancer Res 2005
:
As a
result of HSP90 modulated
HIF-1 activity, the levels of the tumor-relevant HIF-1 downstream targets
carbonic anhydrase IX , prolyl-4-hydroxylase domain protein 3, and vascular endothelial growth factor were increased or decreased after low-dose or high-dose treatment, respectively
Hong et al., Lab Invest 2006
(Liver Diseases) :
Inactivation of the VHL gene resulted in
hypoxia-inducible factor (HIF)-1alpha stabilization and
induction of its target genes, VEGF and
CAIX , in mouse embryonic fibroblasts ( MEFs )
Alchera et al., Hepatology 2008
:
CAIX expression was also
prevented by interfering with the transcriptional activity of
HIF-1 using a dominant negative HIF-1beta subunit
Liao et al., BMC developmental biology 2009
(Anoxia) :
We examined expression of CAIX, CAXII and HIF-1alpha in the developing human fetus and postnatal tissues to determine whether expression of
CAIX and CAXII is exclusively
regulated by
HIF-1
Holotnakova et al., J Med Virol 2010
(Carcinoma, Hepatocellular) :
Hypoxia-inducible factor 1 (HIF-1) is the main transcriptional
activator of
CA9
Berchner-Pfannschmidt et al., Biol Chem 2010
(Osteosarcoma) :
Here, the effects of NANT in inhibiting recombinant PHD2 and up-regulating of HIF-1 and
HIF-1 mediated
carboanhydrase-9 (CA9) mRNA expression were compared in living cells with the NO donors N-nitrosomelatonin ( NOMela ) and S-nitrosoglutathione ( GSNO ) under normoxic and hypoxic conditions
Chiche et al., Ann Endocrinol (Paris) 2013
:
We reported that targeting these pHi regulated processes through inhibition of either
HIF-1 induced
CAIX/CAXII or HIF-1 induced MCT4, MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis generated ATP levels and tumor growth