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CD28 — LAT

Text-mined interactions from Literome

Tsuchida et al., Eur J Immunol 1999 : CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation ... We show in the present report that CD28 ligation induces tyrosine phosphorylation of LAT ... CD28 induced tyrosine phosphorylation of LAT was rapid, as it was apparent within 1 min of CD28 ligation, reached a peak by 5 min, and declined thereafter ... The concurrent ligation of CD28 and TCR increased tyrosine phosphorylation of LAT
Martin et al., J Exp Med 2001 : Consistent with this, CD28 increased the presence of the linker of activated T cells (LAT) in purified membrane rafts, while CTLA-4 coligation effectively blocked this increase
Xie et al., J Immunol 2013 : Although LAT was indispensable for TCR/CD28 induced TRAF6 ubiquitination and its ligase activity, RNA interference induced TRAF6 knockdown in T cells decreased TCR/CD28 induced LAT ubiquitination, tyrosine phosphorylation, and association with tyrosine kinase ZAP70