Gene interactions and pathways from curated databases and text-mining

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ADAM17 — TNF

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Schlomann et al., J Neurosci 2000 (Heredodegenerative Disorders, Nervous System) : In primary astrocytes from wild-type and WR mice, in primary cerebellar neurons, and in mouse motoneuron-like NSC19 cells, ADAM8 expression was induced up to 15-fold by mouse TNF-alpha , in a dose dependent manner ... In both cell types, ADAM8 was also induced by human TNF-alpha , indicating that TNF receptor type I ( p55 ) is involved
Hansen et al., J Immunol 2000 (Lymphoma) : Hence, TACE does not only control the release of TNF-alpha , but also that of sCD30
Hurtado et al., Neuropharmacology 2001 (Brain Ischemia) : TACE enzymatic activity from OGD exposed slices was significantly inhibited by cycloheximide, suggesting that de novo synthesis of TACE contributes to TNF-alpha release after ischaemia ... Taken together, these data demonstrate that ( 1 ) TACE/ADAM17 activity accounts for the majority of TNF-alpha shedding after OGD in rat forebrain slices, ( 2 ) an increase in TACE expression contributes , at least in part, to the rise in TNF-alpha after OGD and ( 3 ) iNOS expression in OGD subjected brain slices results from TACE activity and subsequent increase in TNF-alpha levels
Ohta et al., J Rheumatol 2001 (Arthritis, Rheumatoid...) : Expression and function of tumor necrosis factor-alpha (TNF-alpha) converting enzyme ( TACE ) in synovia of patients with rheumatoid arthritis ( RA ) were examined to investigate posttranslational regulation of TNF-alpha production by TACE in RA ... A synthetic TACE inhibitor significantly reduced the release of TNF-alpha and p75 TNF receptor from RA ST cells
Kottirsch et al., J Med Chem 2002 : The best compound inhibits MMPs and TACE with nanomolar potency and inhibits the release of TNFalpha from cells with an IC50 of 48 nM
Lee et al., Protein Sci 2002 : Tumor necrosis factor-alpha (TNF-alpha) converting enzyme ( TACE/ADAM-17 ) is responsible for the release of TNF-alpha , a potent proinflammatory cytokine associated with many chronic debilitating diseases such as rheumatoid arthritis
Wang et al., J Biol Chem 2003 : Histamine induced shedding is blocked by TNF-alpha protease inhibitor, an inhibitor of TNF-alpha converting enzyme , and through the H1 receptor via a MEK-1/p42 and p44 mitogen activated protein kinase pathway
Li et al., J Huazhong Univ Sci Technolog Med Sci 2002 : In order to investigate the effects of LPS on the TACE gene transcription and expression and its regulating effect on the TM-TNF secretion, in vitro studies were carried out on HL-60 cells stimulated by LPS
Wang et al., J Huazhong Univ Sci Technolog Med Sci 2003 (Inflammation) : It was concluded that all the three types of TACE inhibitors can regulate the expression of TACE at different levels and inhibit sTNF alpha secretion, indicating TACE is a novel target for inflammation therapy
Meli et al., J Neuroimmunol 2004 (Disease Models, Animal...) : We investigated the pharmacokinetics and the effect of TNF484 , a water-soluble hydroxamate based inhibitor of MMP and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis
Bzowska et al., Eur J Biochem 2004 : Therefore, ADAM17 dependent depletion of membrane bound tumor necrosis factor receptors from endothelial cells might constitute a mechanism of self-protection in states of prolonged immunostimulation
Satoh et al., Eur J Heart Fail 2004 (Heart Failure) : These observations suggest that TACE in PBMC is an important regulator of TNF-alpha maturation, meaning that TACE may be a potential target for the inhibition of cellular TNF-alpha production in CHF
Shimoda et al., Clin Sci (Lond) 2005 (Arrhythmias, Cardiac...) : To investigate the clinical significance of the TACE-TNF-alpha system in AMI, we examined TACE mediated TNF-alpha synthesis in PBMCs ( peripheral blood mononuclear cells ), which are a possible source of TNF-alpha in AMI ... TACE mediated TNF-alpha production was evaluated in cultured PBMCs with PMA, which is known to activate TACE ... These results demonstrate that TACE mediated TNF-alpha maturation in PBMCs may play an important role in poor outcomes from AMI, suggesting that TACE may be a potential target for the inhibition of cellular TNF-alpha production in AMI
Pradillo et al., J Cereb Blood Flow Metab 2005 (Brain Ischemia) : In summary, these data show that IPC produces neuronal upregulation of TACE and TNFR1, and that the pathway TACE/TNF-alpha/TNFR1/NF-kappaB is involved in IT
Kresse et al., J Immunol 2005 (Drug-Induced Liver Injury...) : Melphalan increased membrane bound but not secreted TNF in Kupffer cells and inhibited recombinant TNF-alpha converting enzyme in vitro
Jarry et al., Br J Pharmacol 2006 (Colitis, Ischemic) : Human colonic myocytes are involved in postischemic inflammation through ADAM17 dependent TNFalpha production
Federici et al., J Clin Invest 2005 (Diabetes Mellitus...) : Unchecked TACE activity causes an increase in levels of soluble TNF-alpha , which subsequently promotes diabetes and vascular inflammation
Malemud et al., Frontiers in bioscience : a journal and virtual library 2006 (Arthritis...) : Adamlysins are membrane bound MMPs that also degrade aggrecan, but more importantly, one ADAM family member ( i.e.ADAM-17 ) is a tumor necrosis factor-alpha (TNF-alpha) converting enzyme ( TACE ) that activates pro-TNF-alpha
Zhan et al., J Cell Sci 2007 (Mechanotransduction, Cellular) : In addition, conditioned medium from stretched myoblast cultures activated p38 in unstretched myoblasts, which required TACE activity in the donor myoblasts, and TNF-alpha receptors in the recipient myoblasts
Tellier et al., J Cell Physiol 2008 : HDLs reduced the cholesterol and proteins ( including ADAM17 ) content of lipid rafts and triggered the ADAM17 dependent cleavage of TNF in the non-raft region of the membrane
Canault et al., Am J Pathol 2007 (Atherosclerosis) : We sought to examine whether TACE/ADAM17 is present on human plaque MPs and whether these MPs would affect TNF and TNFR-1 cellular shedding
Charbonneau et al., J Biol Chem 2007 (Anoxia...) : Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells
Rousseau et al., J Cell Sci 2008 (MAP Kinase Signaling System) : Therefore, although TACE activity per se is not required for the LPS stimulated cell surface expression of pre-TNF alpha , the phosphorylation of this protease might contribute to, or be required for, the cell surface expression of the pre-TNF alpha-TACE complex
Hiraoka et al., Biochem Biophys Res Commun 2008 : A peptide cleavage assay in vitro showed that recombinant NRDc enhances the cleavage of TNF-alpha induced by TACE
Brennan et al., Eur J Immunol 2008 : In the presence of IL-10, TNF-alpha production and activation of surface TACE was significantly inhibited
Haga et al., Proc Natl Acad Sci U S A 2008 : Modulation of TNF-alpha converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry
Kim et al., J Neurosci 2008 (Alzheimer Disease...) : Accordingly, it is possible that TACE inhibitors could reduce TNFalpha levels without increasing Abeta levels within the AD brain
Fréour et al., Int J Mol Med 2009 (Inflammatory Bowel Diseases) : TNF-alpha production and the bioavailability of its receptors on the cell surface are regulated by TACE ( TNF-alpha converting enzyme ), a pleiotropic metalloprotease also known as ADAM17, and its specific inhibitor TIMP3
Mol et al., Toxicology 2009 (Blister) : Since TACE is involved not only in degradation of cell-matrix adhesion structures, but also in ectodomain shedding of ligands for epidermal growth factor receptor (EGFR) and in release of TNFalpha , these results imply TACE mediated pathways as a new concept in HD toxicity
Estrella et al., Am J Respir Cell Mol Biol 2009 (Rhinitis, Allergic, Perennial...) : In contrast with the other HB-epidermal growth factor sheddases, ADAM-10 and -17, TNF-alpha in vitro increased the expression of ADAM-12 by AEC, an effect amplified by IL-4 and IL-13
Cesaro et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colitis...) : TNF-alpha induced an early upregulation of ADAM17 in T84 cells, whereas PMNL adhesion, H ( 2 ) O ( 2 ), or epithelial tight junction opening alone did not affect the amount of ADAM17
Nikolaidis et al., Shock 2010 : Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production
Sisto et al., Int Immunol 2009 (Sjogren's Syndrome) : Our study demonstrated a dose dependent increase of TACE messenger RNA ( mRNA ) expression in anti-Ro/SSA Abs treated SGEC, followed by internalization, pro-domain shedding and activation of TACE protein, suggesting that increased TACE activity is necessary for the release of TNF-alpha observed in anti-Ro/SSA Abs stimulated SGEC
Sisto et al., Immunobiology 2010 (Autoimmune Diseases...) : Anti-Ro/SSA autoAbs determines TACE pro-domain shedding suggesting that TACE activity is necessary for the release of TNF-a observed in anti-Ro/SSA autoAbs stimulated cells
Adrain et al., Science 2012 : Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
Dreymueller et al., EMBO Mol Med 2012 (Inflammation...) : Induced vascular permeability, oedema formation, release of TNF-a and IL-6 and pulmonary leukocyte recruitment were all markedly reduced by GW280264X or endothelial adam17-knockout
Perna et al., J Cell Biochem 2013 (Inflammation) : Hydrogen sulfide reduces cell adhesion and relevant inflammatory triggering by preventing ADAM17 dependent TNF-a activation
Waheed et al., Mol Biol Cell 2013 : Central role of the exchange factor GEF-H1 in TNF-a induced sequential activation of Rac, ADAM17/TACE , and RhoA in tubular epithelial cells
McMahan et al., Am J Physiol Gastrointest Liver Physiol 2013 (Inflammation) : We conclude that ADAM17 regulates TNF , TNFR1, and AR in the liver, and its expression in both hepatocytes and myeloid cells is important for TNF regulation after LPS injury or 2/3 PH, but is not required for liver regeneration
Fiorucci et al., Aliment Pharmacol Ther 1998 : TACE inhibitors prevent TNFalpha release and protect against TNFalpha mediated disease ... Agents that prevent TNFalpha mRNA transcription, e.g. lisophylline, PGE2, interleukin-10 and 8-BrcAMP, or TACE inhibitors, e.g. EDTA, TAPI-2 and BB-3103, inhibit TNFalpha release and protect rats against gastric mucosal injury induced by oral administration of aspirin