Kapoor-Vazirani et al., Cancer Res 2008
(Breast Neoplasms) :
Down-regulation of hMOF or another component of the MSL complex resulted in a gene-specific decrease in H4K16Ac , loss of nucleosome positioning, and silencing of TMS1
Kapoor-Vazirani et al., Mol Cell Biol 2011
:
These data indicate that H4K20me3 invokes gene repression by antagonizing hMOF mediated H4K16Ac and suggest that overcoming Pol II pausing might be a rate limiting step in achieving tumor suppressor gene reactivation in cancer therapy