UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MAX

MAX — SUPT7L

Pathways - manually collected, often from reviews:

NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → nucleus (EP300/CREBBP) (transcription, activates) Greenberg et al., Oncogene 1999, Faiola et al., Mol Cell Biol 2005, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, assay, reporter gene, physical interaction
NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → MYC/Max complex (MYC-MAX) (modification, collaborate) McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: TAF9 (TAF9) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database C-MYC pathway: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → nucleus (EP300/CREBBP) (transcription, activates) Bouchard et al., EMBO J 1999, Bouchard et al., Genes Dev 2001, Vervoorts et al., EMBO Rep 2003
Evidence: mutant phenotype, assay, reporter gene, physical interaction
NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → HSP60 (HSPD1) (transcription, activates) Frank et al., Genes Dev 2001, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, physical interaction