◀ Back to SHC1

PTK2 — SHC1

Pathways - manually collected, often from reviews:

• BioCarta pten dependent cell cycle arrest and apoptosis: Integrin-beta/SHC/SOS-1/GRB2 complex (ITGB1-SHC1-SOS1-GRB2) → FAK (PTK2) (modification, activates)
• KEGG Focal adhesion: PTK2 → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• WikiPathways Focal Adhesion: PTK2 → SHC1/SHC3 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: PTK2 — SHC1 (coimmunoprecipitation) Schlaepfer et al., J Biol Chem 1997
• IRef Biogrid Interaction: SHC1 — PTK2 (physical association, affinity chromatography technology) Hecker et al., Cancer Res 2002*
• IRef Hprd Interaction: PTK2 — SHC1 (in vitro) Hecker et al., Cancer Res 2002*
• IRef Hprd Interaction: PTK2 — SHC1 (in vivo) Hecker et al., Cancer Res 2002*
• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Ophid Interaction: PTK2 — SHC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PTK2 — SHC1 (aggregation, confirmational text mining) Hecker et al., Cancer Res 2002*

Text-mined interactions from Literome

Nagai et al., J Biol Chem 1995 : However, it is not clear which PTK is involved in the phosphorylation of Shc , resulting in coupling to the Ras pathway
van der Geer et al., Curr Biol 1996 : These results have suggested that Shc is a prominent effector of protein-tyrosine kinase signalling