Stein et al., J Steroid Biochem Mol Biol 2009
(Breast Neoplasms) :
Estrogen related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells ... Importantly, we demonstrate in this study that activation of ERRalpha in several different breast cancer cell lines leads to a significant increase in VEGF mRNA expression, an activity that translates into an increase in VEGF protein secretion ... These findings suggest that ERRalpha dependent induction of VEGF may contribute to the overall negative phenotype observed in tumors in which ERRalpha is expressed and provide validation for its use as a therapeutic target in cancer
Chinsomboon et al., Proc Natl Acad Sci U S A 2009
(Peripheral Vascular Diseases) :
The orphan nuclear receptor ERRalpha mediated the induction of VEGF by PGC-1alpha, and mice lacking ERRalpha also failed to increase vascular density after exercise