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GAST — MMP7

Text-mined interactions from Literome

Varro et al., Am J Physiol Gastrointest Liver Physiol 2007 (Carcinoid Tumor...) : Here, we describe the regulation of gastric MMP-7 by gastrin and the potential significance for recruiting and maintaining myofibroblast populations ... Gastrin stimulated MMP-7-luc expression in both AGS-G ( R ) and primary human gastric epithelial cells ... In conclusion, stimulation of gastric MMP-7 by elevated plasma gastrin may activate epithelial-mesenchymal signaling pathways regulating myofibroblast function via MAPK and PI3K pathways and contribute to stromal deposition in ECL cell carcinoid tumors
Yin et al., Gut 2010 (Cell Transformation, Neoplastic...) : The upregulation of MMP-7 by pathogenic H pylori is partially dependent on gastrin and may have a role in the development of gastric cancer, potentially through EMT, by indirectly increasing levels of soluble HB-EGF