Johnston et al., Ann Neurol 2001
(Multiple Sclerosis) :
Previously, we have reported that the adenosine A1 receptor ( A1AR ) regulates tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) expression and exhibits diminished function in patients with multiple sclerosis ( MS ; Mayne et al., Ann Neurol 1999 ; 45 : 633-639 )
Biber et al., Biol Psychiatry 2008
(Seizures...) :
Interleukin-6 upregulates neuronal adenosine A1 receptors : implications for neuromodulation and neuroprotection ... We now report that IL-6 increases the expression and function of the neuronal adenosine A1 receptor , with relevant consequences to synaptic transmission and neuroprotection
Vazquez et al., J Neurochem 2008
(Encephalitis) :
Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum : an in vivo microdialysis study ... Stimulation of adenosine A2B receptors on astrocytes in vitro leads to the increased synthesis and secretion of IL-6 Feng et al., Br J Pharmacol 2010
:
Stimulation of adenosine A ( 2B ) receptors induces interleukin-6 secretion in cardiac fibroblasts via the PKC-delta-P38 signalling pathway