Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
BAD
→
MAPK3
(directlyIncreases, BAD Activity)
Rice et al., Cancer Res 2003* Evidence: In tumor cells, activation of extracellular-regulated kinase (ERK) 1/2 results in phosphorylation of several ERK1/2 effectors, including the proapoptotic protein Bad. Phosphorylation of Ser112 by ERK1/2 inactivates Bad and protects the tumor cell from apoptosis.