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ITGA10 — PTK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTK2 → Complex of ITGA10-ITGB1 (increases, ITGA10/ITGB1 Activity, PTK2 Activity)
  Evidence: The expression and action of integrins are predominantly localized to the focal adhesion complex as originally demonstrated in fibroblasts. Focal adhesion complexes are the structural connection between the ECM and the cytoskeleton. Here, transmembrane signaling is mediated by integrins that cluster with dozens of cytoskeletal proteins and signaling molecules. Interestingly, integrins not only convey signals from the ECM into the cell (outside-in), but also react to cytoplasmic alterations by al...
• KEGG Regulation of actin cytoskeleton: ITGA1/ITGA10/ITGA11/ITGA2/ITGA2B/ITGA3/ITGA4/ITGA5/ITGA6/ITGA7/ITGA8/ITGA9/ITGAD/ITGAE/ITGAL/ITGAM/ITGAV/ITGAX/ITGB1/ITGB2/ITGB3/ITGB4/ITGB5/ITGB6/ITGB7/ITGB8 → Complex of BCAR1-CRK-CRKL-PTK2 (protein-protein, activation)
  
• NCI Pathway Database CXCR4-mediated signaling events: alpha-beta1 Integrin (ITGA8/ITGB1/ITGA10/ITGB1/ITGA6/ITGB1/ITGA1/ITGB1/ITGA3/ITGB1/ITGA2/ITGB1/ITGAV/ITGB1/ITGA11/ITGB1/ITGA4/ITGB1/ITGA7/ITGB1/ITGA5/ITGB1/ITGA9/ITGB1) → FAK/p130 Cas/Paxillin complex (PTK2-BCAR1-PXN) (cell adhesion, collaborate)
  Okabe et al., J Hematother Stem Cell Res 2002, Glodek et al., Leukemia 2007
  Evidence: mutant phenotype, assay