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CDH1 — PTEN

Text-mined interactions from Literome

Li et al., Biochem Biophys Res Commun 2007 (Breast Neoplasms) : We reported here that PTEN expression could be controlled by overexpression or knock-down of E-cadherin in several mammary carcinoma cell lines
Fournier et al., Cancer Res 2009 : These studies provide evidence that E-cadherin regulates both the PTEN protein levels and its recruitment to cell-cell junctions in three-dimensional lrECM, indicating a dynamic reciprocity between architectural integrity and the levels and localization of PTEN
Song et al., Cell 2011 (Prostatic Neoplasms) : Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase independent manner ... Here we show that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1 , and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex ... We find that nuclear exclusion but not phosphatase inactivation of PTEN impairs APC-CDH1
Lau et al., Oncogene 2011 (Ovarian Neoplasms) : Finally, we found that E-cadherin negatively regulates tumor cell growth, in part, by positively regulating PTEN expression via ß-catenin mediated Egr1 regulation, thus influencing PI3K/Akt signaling
Chen et al., Mol Med Report 2013 (Breast Neoplasms) : miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin mediated PTEN/Akt signaling