◀ Back to MAPK14
CSF2 — MAPK14
Text-mined interactions from Literome
Hu et al., Cell Growth Differ 2000
(Leukemia, Myeloid...) :
In contrast, treatment of TF-1a cells with
granulocyte/macrophage-colony stimulating factor induced only transient
activation of MEK and p44/42
MAPK ( 10-20 min ) and an increase ( approximately 50 % ) in cell proliferation, without any change in cellular differentiation
Lehman et al., Am J Physiol Cell Physiol 2001
:
Interestingly, peripheral blood neutrophils expressed the highest ( 16-fold )
MAPK activation level in
response to
GM-CSF
Zubkov et al., Stroke 2001
(Disease Models, Animal...) :
( 6 ) Hemolysate, oxyhemoglobin, and bloody
CSF significantly
increased MAPK activity in the rabbit basilar artery ... ( 7 ) U0126 abolished the
effect of hemolysate, oxyhemoglobin, or bloody
CSF on
MAPK activation
Suzuki et al., J Immunol 2001
(Inflammation) :
In addition,
GM-CSF- and TNF induced superoxide release and adherence were
inhibited by PD98059 MAPK/ERK kinase inhibitor ) as well as SB203580 ( p38
MAPK inhibitor ), suggesting possible involvement of ERK and p38 MAPK in superoxide release and adherence induced by these cytokines
Hallsworth et al., Am J Respir Crit Care Med 2001
(Asthma...) :
In the present study, we examined a
requirement for
mitogen activated protein ( MAP ) kinase activation for interleukin (IL)-1beta stimulated
GM-CSF , RANTES, and eotaxin release
Irusen et al., J Allergy Clin Immunol 2002
(Asthma) :
Activation of p38
MAPK by IL-2 and IL-4, as shown by means of phosphorylation of activated transcription factor 2, resulted in GR phosphorylation and
reduced dexamethasone repression of LPS stimulated
GM-CSF release
Cárcamo et al., Blood 2002
:
Vitamin C suppressed
GM-CSF dependent phosphorylation of the signal transducer and activator of transcription 5 ( Stat-5 ) and
mitogen activated protein ( MAP ) kinase ( Erk1 and Erk2 ) in a dose dependent manner as was phosphorylation of MAP kinase induced by both interleukin 3 (IL-3) and GM-CSF in HL-60 cells
Wong et al., Am J Respir Cell Mol Biol 2003
:
IL-3, IL-5, and
GM-CSF could
enhance p38
MAPK and NF-kappaB activity and induce ICAM-1, CD11b, and CD18 expressions on eosinophils
Kutsuna et al., Am J Physiol Cell Physiol 2004
:
These findings suggest that TNF,
GM-CSF , and G-CSF
induce actin depolymerization and morphological changes through activation of ERK and/or p38
MAPK and that cytokine induced actin reorganization may be partly responsible for the inhibitory effect of these cytokines on neutrophil chemotaxis
Pei et al., Acta Pharmacol Sin 2003
(MAP Kinase Signaling System) :
And mitogen activated protein kinase (
MAPK ) inhibitor, PD 98059 ( 10 micromol/L ), completely
blocked IGF-1,
GM-CSF , and EGF induced expression of Cbfa1 promoter activity ( P < 0.01 )
Tortorella et al., Mech Ageing Dev 2004
:
No changes in
GM-CSF induced p38
MAPK phosphorylation were observed
Baumann et al., Leuk Res 2005
:
Although both
GM-CSF and G-CSF
activate p42/44
MAPK in neutrophil progenitors, the ability of G-CSF to cause MAPK activation is lost in mature neutrophils, while GM-CSF exposure still causes activation
Senokuchi et al., J Biol Chem 2005
:
Statins did not inhibit Ox-LDL induced
GM-CSF production, but
inhibited GM-CSF induced p38
MAPK activation ...
GM-CSF induced p38
MAPK activation and macrophage proliferation was partially inhibited by overexpression of dominant negative Ras and completely by that of RhoA ...
GM-CSF induced p38
MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF induced p38 MAPK phosphorylation by statins ... In conclusion, statins inhibited
GM-CSF induced Ras- or RhoA-p38
MAPK signal cascades, thereby suppressing Ox-LDL induced macrophage proliferation
Ip et al., Immunopharmacol Immunotoxicol 2005
:
IL-3, IL-5, and
GM-CSF could
augment the phosphorylation of p38
MAPK and nucleus translocation of NF-kappaB in eosinophils
Smith et al., Br J Pharmacol 2006
(Pneumonia) :
p38 MAPK may regulate cytokine production, therefore, the
effect of two p38
MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha,
GM-CSF and IL-8 from human macrophages was investigated
Chen et al., Zhonghua Nan Ke Xue 2006
(Neoplasms, Hormone-Dependent...) :
[ Role of
MAPK signal transduction pathway phosphorylation
induced by
granulocyte-macrophage-colony stimulating factor in the proliferation of hormone independent prostate cancer ]
ten Hove et al., Mol Immunol 2007
:
Differential regulation of TNFalpha and
GM-CSF induced activation of P38
MAPK in neutrophils and eosinophils
Zaheer et al., J Neurochem 2007
(Encephalitis...) :
Inhibition of p38
MAPK or NF-kappaB by specific inhibitors
prevented GM-CSF production
Uemura et al., Int J Lab Hematol 2009
(Leukemia, Neutrophilic, Chronic) :
We also showed that stat3 and
mitogen activated protein kinase activation by G-CSF or
GM-CSF in the patient 's neutrophils were significantly lower than those in healthy donor neutrophils
Ha et al., FEBS J 2008
(Arthritis, Rheumatoid) :
These results imply that
GM-CSF signaling
activates mitogen activated protein kinase , followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis
Liu et al., Invest Ophthalmol Vis Sci 2008
:
Poly ( I:C ) -induced expression of IL-6, IL-8,
G-CSF , MIP-1beta, exotaxin, RANTES, and ICAM-1 was
inhibited differentially by the
MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II
Zhou et al., PloS one 2009
(MAP Kinase Signaling System) :
This identifies a novel role for
MEK/MAPK mediated
cytostatic factor (CSF) activity during meiosis in membrane protein trafficking in mouse oocytes, and shows for the first time that selective retrieval of membrane proteins is a feature of meiosis in mammalian oocytes
Ishii et al., J Biol Chem 2009
:
AICAR suppressed
GM-CSF induced macrophage proliferation without suppressing p38
MAPK/Akt signaling
Knobloch et al., Thorax 2009
:
ET-1- and TNFalpha induced
GM-CSF expression were both
reduced by bosentan as well as by specific inhibition of either ET ( A ) R, ET ( B ) R, p38 (
MAPK ) or ERK-1/-2
Dohgu et al., Journal of neuroinflammation 2011
:
These results show that p44/42 and p38
MAPK signaling pathways
mediate the LPS enhanced release of IL-6 and
GM-CSF
Chatterjee et al., J Biol Chem 2013
(Cholera...) :
These vesicles
induced expression of proinflammatory cytokines such as IL-8 and
GM-CSF and chemokines such as CCL2, CCL20, and thymic stromal lymphopoietin in epithelial cells through activation of
MAPK and NF-?B pathways in NOD1 dependent manner
Reece et al., Immunology 2013
:
We show for the first time that LPS stimulation of CB progenitor cells results in autocrine activation of p38
MAPK dependent
GM-CSF secretion facilitating Eo/B differentiation ex vivo
Büscher et al., Mol Cell Biol 1995
:
Expression of a dominant negative ras mutant reduced, but did not abolish,
CSF-1 mediated stimulation of MEK and
MAPK
Jiao et al., Exp Hematol 1997
:
Despite the heightened growth responses of the motheaten macrophages to GM-CSF, there were no marked differences between motheaten macrophages and normal controls in
GM-CSF induced phosphorylation of GM-CSFR beta, Jak2, STAT5 and
MAPK , indicating that these molecules are not major HCP substrates in GM-CSF signaling
Hiraguri et al., J Allergy Clin Immunol 1997
:
Granulocyte-macrophage
colony stimulating factor and IL-5
activate mitogen activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils
Villunger et al., Br J Haematol 1998
(Multiple Myeloma...) :
The expressed cytokine receptor alpha-subunit was able to constitute a functional signalling complex with the ubiquitously expressed GM-CSFRbeta subunit, as demonstrated by the fact that
GM-CSF induced the p21-ras/mitogen activated protein kinase (
MAPK ) signalling cascade in malignant plasma cell lines
McLeish et al., J Leukoc Biol 1998
:
The phosphatidylinositol 3-kinase inhibitor, wortmannin, attenuated
stimulation of ERKs and p38
MAPK by
GM-CSF , but not TNF-alpha ... Our data suggest that TNF-alpha and
GM-CSF activate ERKs and p38
MAPK by different signal transduction pathways
Suzuki et al., Blood 1999
:
MEK inhibitor ( PD98059 ) reduced tyrosine phosphorylation of ERK, but not p38
MAPK ,
induced by G-CSF,
GM-CSF , or TNF ...
GM-CSF- or TNF induced superoxide ( O2- ) release was
inhibited by p38
MAPK inhibitor ( SB203580 ) in a dose dependent manner, suggesting the possible involvement of p38 MAPK in GM-CSF- or TNF induced O2- release
Aoshiba et al., J Immunol 1999
:
Granulocyte-macrophage
CSF and anti-Fas Ab, which altered the rate of apoptosis, did not
affect phosphorylation and activation of
p38-MAPK