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GRAP2 — MMP2
Text-mined interactions from Literome
Ko et al., Mol Cancer Ther 2005
(Carcinoma...) :
ERK inhibitor ( PD98059 ) and PKC inhibitors ( GF-109203X and H-7 ), but not
p38 inhibitor ( SB203580 ) or c-jun-NH2-kinase inhibitor ( SP600125 ), significantly
inhibited TPA induced
MMP-2 protein expression, with reduced ERK phosphorylation and c-Jun protein expression
Park et al., Cancer Res 2006
(Glioblastoma...) :
In addition, inhibitors of epidermal growth factor receptor ( EGFR ; AG490 and AG1478 ), Src ( PP2 ), and p38 ( SB203580 ), EGFR neutralizing antibody, and transfection of DN-Src and
DN-p38 significantly
blocked IR-induced Akt phosphorylation and
MMP-2 secretion
Song et al., Cancer Res 2006
(Breast Neoplasms...) :
Activating transcription factor 2 mediates
matrix metalloproteinase-2 transcriptional activation
induced by
p38 in breast epithelial cells
Cheung et al., Cancer Res 2006
(Neoplasm Invasiveness...) :
In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or
p38 mitogen activated protein kinase, signaling pathway was
critical for GnRH mediated up-regulation of
MMP , cell invasion, and motility
Sanka et al., Invest Ophthalmol Vis Sci 2007
:
Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents, including cytochalasin D, latrunculin A, ethacrynic acid ( ECA ), a Rho kinase inhibitor ( Y-27632 ), and H-7 ( serine/threonine kinase inhibitor ), were examined for changes in actin cytoskeletal organization by phalloidin staining,
MMP-2 activation by gelatin zymography, expression of MT1-MMP by quantitative real-time PCR analysis, levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ), and
activation of
p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting ... Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents, including cytochalasin D, latrunculin A, ethacrynic acid ( ECA ), a Rho kinase inhibitor ( Y-27632 ), and H-7 ( serine/threonine kinase inhibitor ), were examined for changes in actin cytoskeletal organization by phalloidin staining,
MMP-2 activation by gelatin zymography, expression of MT1-MMP by quantitative real-time PCR analysis, levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ), and
activation of
p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting
Chang et al., Evidence-based complementary and alternative medicine : eCAM 2011
:
Schwann Cell Migration Induced by Earthworm Extract via
Activation of PAs and
MMP2/9 Mediated through ERK1/2 and
p38
Hsu et al., J Cell Physiol 2012
(Colonic Neoplasms) :
After administration of inhibitors including QNZ ( NF?B inhibitor ), LY294002 ( Akt activation inhibitor ), U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ) or SP600125 ( JNK1/2 inhibitor ), E ( 2 ) -downregulated cell migration and expression of
MMP-2 and MMP-9 in LoVo cells is markedly
inhibited only by
p38 MAPK inhibitors, SB203580
Yen et al., TheScientificWorldJournal 2013
(Gingival Neoplasms...) :
After CTXIII treatment, the
MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and
p38-MAPK was
increased independent of ERK phosphorylation
Pan et al., Mol Biol Rep 2013
(MAP Kinase Signaling System...) :
Furthermore, SDF-1a induced p38 phosphorylation and
p38 inhibition
reduced both the level of SDF-1a stimulated
MMP-2 expression and PANC-1 cell invasion