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CTNNB1 — NEUROD4
Text-mined interactions from Literome
Lyu et al., J Biol Chem 2003
(Carcinoma, Embryonal) :
Overall, our data show that Wnt-3a/canonical
beta-catenin signaling through the down-regulation of Axin may
play an important role in
neuronal differentiation
Uemura et al., J Neurosci Res 2003
:
To elucidate the
role of presenilin
1-beta-catenin interaction in
neuronal differentiation , we established SH-SY5Y cells stably expressing wild-type presenilin 1, P117L mutant presenilin 1, which is linked to the early-onset familial form of Alzheimer 's disease, and D385A mutant presenilin 1, which has no aspartyl proteinase activity
Israsena et al., Dev Biol 2004
:
However, overexpression of
beta-catenin in the absence of FGF2
enhances neuronal differentiation
Hirabayashi et al., Development 2004
:
Overexpression of Wnt7a or of a stabilized form of
beta-catenin in mouse cortical NPC cultures
induced neuronal differentiation even in the presence of Fgf2, a self-renewal promoting factor in this system ... Importantly, stabilized
beta-catenin did not
induce neuronal differentiation of cortical NPCs at earlier developmental stages, consistent with previous reports indicating self-renewal promoting functions of Wnts in early NPCs
Shimizu et al., Mol Cell Biol 2008
:
The nuclear accumulated
beta-catenin leads to cell proliferation by activating LEF/TCF transcription factors and concurrently
inhibits neuronal differentiation by potentiating the Notch1-RBP-Jkappa signaling pathway