Barouch et al., J Leukoc Biol 2001
(MAP Kinase Signaling System) :
NGF induced phosphorylation and activation of extracellular signal regulated kinase, Erk1/Erk2 and c-Jun amino-terminal kinase, whereas it did not induce phosphorylation of p38 mitogen activated protein kinase
Yamdeu et al., Anesthesiology 2011
(Pain) :
p38 Mitogen activated protein kinase activation by nerve growth factor in primary sensory neurons upregulates µ-opioid receptors to enhance opioid responsiveness toward better pain control
Kummer et al., J Biol Chem 1997
:
In the presence of NGF , p38 activity and the number of apoptotic cells was very low ( approximately 1.0 % )