◀ Back to RASA1
PDGFRB — RASA1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RasGAP (RASA1)
(modification, collaborate)
Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
RasGAP (RASA1)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB)
(modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
None
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
Reactome Reaction:
PDGFRB
→
RASA1
(indirect_complex)
Kashishian et al., EMBO J 1992*, Kazlauskas et al., Mol Cell Biol 1992*, Heldin et al., Biochim Biophys Acta 1998
-
Reactome Reaction:
PDGFRB
→
RASA1
(reaction)
Kashishian et al., EMBO J 1992*, Kazlauskas et al., Mol Cell Biol 1992*, Heldin et al., Biochim Biophys Acta 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
PDGFRB
—
RASA1
Marengere et al., J Biol Chem 1992*, Anderson et al., Science 1990*, Larose et al., Oncogene 1993*, McGlade et al., EMBO J 1993*
-
IRef Bind Interaction:
PDGFRB
—
RASA1
Kazlauskas et al., Science 1990*
-
IRef Bind Interaction:
PDGFRB
—
RASA1
Roche et al., EMBO J 1996
-
IRef Bind_translation Interaction:
PDGFRB
—
RASA1
(affinity chromatography technology)
Marengere et al., J Biol Chem 1992*, Anderson et al., Science 1990*
-
IRef Bind_translation Interaction:
PDGFRB
—
RASA1
(affinity chromatography technology)
Marengere et al., J Biol Chem 1992*, Larose et al., Oncogene 1993*
-
IRef Bind_translation Interaction:
PDGFRB
—
RASA1
(affinity chromatography technology)
Roche et al., EMBO J 1996
-
IRef Bind_translation Interaction:
PDGFRB
—
RASA1
(coimmunoprecipitation)
Kazlauskas et al., Science 1990*
-
IRef Bind_translation Interaction:
PDGFRB
—
RASA1
(affinity chromatography technology)
Marengere et al., J Biol Chem 1992*
-
IRef Bind_translation Interaction:
PDGFRB
—
RASA1
(coimmunoprecipitation)
Marengere et al., J Biol Chem 1992*, McGlade et al., EMBO J 1993*
-
IRef Biogrid Interaction:
PDGFRB
—
RASA1
(physical association, affinity chromatography technology)
Farooqui et al., Anticancer Res 1999*
-
IRef Biogrid Interaction:
PDGFRB
—
RASA1
(physical association, affinity chromatography technology)
Ekman et al., Oncogene 2002
-
IRef Dip Interaction:
PDGFRB
—
RASA1
(physical association, biophysical)
Myers et al., Ann N Y Acad Sci 1995*
-
IRef Hprd Interaction:
PDGFRB
—
RASA1
(in vivo)
Farooqui et al., Anticancer Res 1999*
-
IRef Intact Interaction:
PDGFRB
—
RASA1
(association, coimmunoprecipitation)
Kashishian et al., EMBO J 1992*
-
IRef Intact Interaction:
PDGFRB
—
RASA1
(association, coimmunoprecipitation)
Kazlauskas et al., Mol Cell Biol 1992*
-
IRef Intact Interaction:
PDGFRB
—
RASA1
(association, coimmunoprecipitation)
Cooper et al., Mol Cell Biol 1993
-
IRef Ophid Interaction:
PDGFRB
—
RASA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PDGFRB
—
RASA1
(aggregation, confirmational text mining)
Ekman et al., Oncogene 2002
Text-mined interactions from Literome
Farooqui et al., Anticancer Res 1999
(Brain Neoplasms...) :
PDGF
stimulated the association of
PDGFR-beta with p85, ras
GTPase activating protein and PLC gamma
Newton et al., J Biol Chem 2005
:
Using a panel of cytoplasmic domain mutants of the chimeric M-CSF/PDGFR-beta, we confirmed that the kinase domain of PDGFR-beta is absolutely required for LRP tyrosine phosphorylation but that
PDGFR-beta mediated
activation of phosphatidylinositol 3-kinase,
RasGAP , SHP-2, phospholipase C-gamma, and Src are not necessary for LRP tyrosine phosphorylation
Vaillancourt et al., Mol Cell Biol 1995
:
beta
PDGF-R regulation of phosphatidylinositol 3-kinase, the
GTPase activating protein of Ras, and the tyrosine phosphatase, Syp, was not required for PC12 cell differentiation