◀ Back to STAT3
AGTR1 — STAT3
Text-mined interactions from Literome
Horiuchi et al., Circ Res 1999
:
In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA transfected rat adult vascular smooth muscle cells ( VSMCs ) inhibited
angiotensin II type 1 (AT1) receptor mediated tyrosine phosphorylation of STAT ( signal transducers and activators of transcription ) 1alpha/beta, STAT2, and
STAT3 without influence on Janus kinase
Omura et al., J Mol Cell Cardiol 2000
(Myocardial Infarction) :
Thus, the transcriptional
activation of
STAT3 through
AT1 receptor may be partially involved in cardiac remodeling after myocardial infarction
Yue et al., Cardiovasc Res 2010
(Cardiomegaly) :
Chronic activation of
AT1R induces unregulated expression of the
Stat3 gene, leading to nuclear accumulation of U-STAT3, which significantly correlated with progression of cardiac hypertrophy
Kandalam et al., Regul Pept 2010
:
Our study showed for the first time that Ang II
induced JAK2/STAT3 phosphorylation and IL-6 secretion through activation of the Ang II
AT(1) receptor in brainstem astrocytes