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FRS2 — GRB2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: None → FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) (modification, collaborate)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) (modification, collaborate)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → None (modification, activates) Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database FGF signaling pathway: SHC (SHC1) → GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: Gab1 (GAB1) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: SHP2 (PTPN11) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) → SHP2/GAB1/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → CBL (CBL) (modification, collaborate) Wong et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → FGFR/FGF/Syndecan-2/FRS2/Cbl/GRB2/SOS1/SHC complex (SDC2-FRS2-CBL-GRB2-SHC1-SOS1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database FGF signaling pathway: CBL (CBL) → FGFR/FGF/Syndecan-2/FRS2/Cbl/GRB2/SOS1/SHC complex (SDC2-FRS2-CBL-GRB2-SHC1-SOS1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002
• NCI Pathway Database FGF signaling pathway: SHC (SHC1) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2/Grb2 complex (SDC2-FRS2-SPRY2-GRB2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2/Grb2 complex (SDC2-FRS2-SPRY2-GRB2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: GRB2/SOS1 complex (GRB2-SOS1) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database FGF signaling pathway: GRB2 (GRB2) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2 complex (SDC2-FRS2-SPRY2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → SOS1 (SOS1) (modification, collaborate) Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Hadari et al., Mol Cell Biol 1998
  Evidence: physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, collaborate)
  Hadari et al., Mol Cell Biol 1998
  Evidence: physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: GRB2/SOS1 complex (GRB2-SOS1) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, collaborate)
  Hadari et al., Mol Cell Biol 1998
  Evidence: physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2/Grb2 complex (SDC2-FRS2-SPRY2-GRB2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2 complex (SDC2-FRS2-SPRY2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database SHP2 signaling: GRB2 (GRB2) → FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: GRB2 (GRB2) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: Gab1 (GAB1) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) → SHP2/GAB/GRB2/FRS2/FGFR/FGF/Syndecan-2 complex (PTPN11-GAB1-GRB2-FRS2-SDC2) (modification, collaborate)
  Ong et al., Proc Natl Acad Sci U S A 2001, Agazie et al., Oncogene 2003, Gotoh et al., Proc Natl Acad Sci U S A 2004, Kanai et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database FGF signaling pathway: FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2/Grb2 complex (SDC2-FRS2-SPRY2-GRB2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: SOS1 (SOS1) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2/Grb2 complex (SDC2-FRS2-SPRY2-GRB2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database FGF signaling pathway: FGFR/FGF/Syndecan-2/FRS2/Sprouty2/Grb2 complex (SDC2-FRS2-SPRY2-GRB2) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2 complex (SDC2-FRS2-SPRY2) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002, Lao et al., J Biol Chem 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: None → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, collaborate)
  Kouhara et al., Cell 1997
  Evidence: mutant phenotype
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, collaborate)
  Kouhara et al., Cell 1997
  Evidence: mutant phenotype
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Kouhara et al., Cell 1997
  Evidence: mutant phenotype
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) → None (modification, activates) Kouhara et al., Cell 1997
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database FGF signaling pathway: GRB2/SOS1/SHC/FRS2/FGFR/FGF/Syndecan-2 complex (FRS2-SDC2-GRB2-SHC1-SOS1) → FGFR1-FGF complex/Sef complex (IL17RD) (MAPKKK cascade, activates)
  Wong et al., Proc Natl Acad Sci U S A 2002, Kovalenko et al., J Biol Chem 2003, Ren et al., Biochem Biophys Res Commun 2007
  Evidence: mutant phenotype, assay
• Reactome Reaction: GRB2 → FRS2 (reaction) Hart et al., Oncogene 2000, Ong et al., Proc Natl Acad Sci U S A 2001, Hadari et al., Proc Natl Acad Sci U S A 2001, Guasch et al., Mol Cell Biol 2001, Demiroglu et al., Blood 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Chen et al., Proc Natl Acad Sci U S A 2004, Takeda et al., Clin Cancer Res 2007, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Taylor et al., J Clin Invest 2009, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998
• Reactome Reaction: GRB2 → FRS2 (indirect_complex) Hart et al., Oncogene 2000, Ong et al., Proc Natl Acad Sci U S A 2001, Hadari et al., Proc Natl Acad Sci U S A 2001, Guasch et al., Mol Cell Biol 2001, Demiroglu et al., Blood 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Agazie et al., Oncogene 2003, Chen et al., Proc Natl Acad Sci U S A 2004, Takeda et al., Clin Cancer Res 2007, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Taylor et al., J Clin Invest 2009, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: FRS2 — GRB2 Kouhara et al., Cell 1997
• IRef Bind_translation Interaction: FRS2 — GRB2 (coimmunoprecipitation) Kouhara et al., Cell 1997
• IRef Bind_translation Interaction: FRS2 — GRB2 (affinity chromatography technology) Kouhara et al., Cell 1997
• IRef Biogrid Interaction: FRS2 — GRB2 (physical association, affinity chromatography technology) Bisson et al., Nat Biotechnol 2011
• IRef Biogrid Interaction: FRS2 — GRB2 (physical association, affinity chromatography technology) Kouhara et al., Cell 1997
• IRef Biogrid Interaction: FRS2 — GRB2 (direct interaction, pull down) Meakin et al., J Biol Chem 1999
• IRef Biogrid Interaction: FRS2 — GRB2 (physical association, affinity chromatography technology) Mason et al., Mol Biol Cell 2004
• IRef Biogrid Interaction: FRS2 — GRB2 (physical association, affinity chromatography technology) Wong et al., Proc Natl Acad Sci U S A 2002
• IRef Biogrid Interaction: FRS2 — GRB2 (physical association, affinity chromatography technology) Ong et al., Biochem Biophys Res Commun 1996
• IRef Biogrid Interaction: FRS2 — GRB2 (direct interaction, unspecified method) Liu et al., Cell communication and signaling : CCS 2012
• IRef Biogrid Interaction: FRS2 — GRB2 (physical association, affinity chromatography technology) Lao et al., J Biol Chem 2006
• IRef Hprd Interaction: FRS2 — GRB2 (in vivo) Wong et al., Proc Natl Acad Sci U S A 2002, Hanafusa et al., Nat Cell Biol 2002*, Ong et al., Biochem Biophys Res Commun 1996, Kouhara et al., Cell 1997
• IRef Hprd Interaction: FRS2 — GRB2 (in vitro) Wong et al., Proc Natl Acad Sci U S A 2002, Hanafusa et al., Nat Cell Biol 2002*, Ong et al., Biochem Biophys Res Commun 1996, Kouhara et al., Cell 1997
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Hadari et al., Mol Cell Biol 1998
• IRef Ophid Interaction: FRS2 — GRB2 (aggregation, confirmational text mining) Kouhara et al., Cell 1997
• IRef Ophid Interaction: FRS2 — GRB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

MacDonald et al., J Biol Chem 2000 : Grb2 binding to TrkA is independent of Shc, FRS-2 , phospholipase Cgamma-1, rAPS, and SH2B and is observed in in vitro binding assays, yeast two-hybrid assays, and in co-immunoprecipitation assays ... Grb2 binding to TrkA is independent of Shc, FRS-2 , phospholipase Cgamma-1, rAPS, and SH2B and is observed in in vitro binding assays, yeast two-hybrid assays, and in co-immunoprecipitation assays
Lo et al., Genetics 2010 : Thus, unlike the vertebrate FGFRs, which require the multi-substrate adaptor FRS2 to recruit Grb2 , EGL-15 can recruit SEM-5/Grb2 directly