UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to RAC1

KALRN — RAC1

Pathways - manually collected, often from reviews:

NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → KALRN (KALRN) (modification, collaborate) Koo et al., BMC cell biology 2007 *
Evidence: assay
NCI Pathway Database Regulation of RAC1 activity: KALRN (KALRN) → RAC1/GTP complex (RAC1) (modification, activates) Koo et al., BMC cell biology 2007 *
Evidence: assay
NCI Pathway Database Arf6 downstream pathway: RAC1/GDP complex (RAC1) → KALRN (KALRN) (modification, collaborate) Koo et al., BMC cell biology 2007 *
Evidence: mutant phenotype
Reactome Reaction: KALRN → RAC1 (reaction) Harrington et al., J Neurosci 2002, Penzes et al., Neuron 2003

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: RAC1 — KALRN (direct interaction, pull down) Alam et al., J Biol Chem 1997 *

Text-mined interactions from Literome

Chakrabarti et al., Mol Cell Biol 2005 : Furthermore, elevated Kalirin expression resulted in catalytic activation of TrkA, as demonstrated by in vitro kinase assays and increased NGF stimulated cellular activation of Rac , Mek, and CREB
Koo et al., BMC cell biology 2007 : Kalirin5 induced Rac1 activation is increased by the expression of wild type Arf6 and decreased by Arf6T27N
Impey et al., Mol Cell Neurosci 2010 : Additionally, we show that the miR132/p250GAP circuit regulates Rac1 activity and spine formation by modulating synapse-specific Kalirin7-Rac1 signaling