◀ Back to PARP1

PARP1 — VEGFA

Text-mined interactions from Literome

Obrosova et al., Int J Mol Med 2004 (Diabetes Mellitus, Experimental...) : In conclusion, PARP is involved in diabetes- and hypoxia induced VEGF production at post-transcriptional level, downstream from the sorbitol pathway activation and oxidative stress
Tawa et al., Circ Res 2010 (Disease Models, Animal...) : These results demonstrate a novel molecular mechanism by which Rap1 and afadin regulate the VEGF- and S1P induced angiogenesis
Zheng et al., Diabetes 2010 (Diabetes Mellitus, Experimental...) : Simvastatin significantly upregulated PGC-1alpha ( P < 0.01 ), subsequently decreased Deltapsim ( P < 0.05 ) and ROS generation ( P < 0.01 ), inhibited PARP activation ( P < 0.01 ), and further reduced VEGF expression ( P < 0.01 ) and p38 MAPK activity ( P < 0.01 )
Sledge et al., Surg Oncol Clin N Am 2010 (Breast Neoplasms) : Novel targeted therapies under development, many currently being examined in the adjuvant setting, are also explored, including anti-vascular endothelial growth factor therapy, poly ( ADP ribose ) polymerase ( PARP ) inhibition for triple negative breast cancers, and agents targeting site-specific metastasis to the bone ( receptor activator of NF-kB [ RANK ] ligand inhibition )
Lakshmikanthan et al., Blood 2011 : Using ECs obtained from Rap1-deficient mice we demonstrate that Rap1b promotes VEGF-VEGFR2 kinase activation and regulates integrin activation ... Importantly, the Rap1b dependent VEGF-VEGFR2 activation is in part mediated via integrin a ( v ) ß ( 3 ) ... These results provide a novel insight into the role of Rap1 in VEGF signaling in ECs
Li et al., J Huazhong Univ Sci Technolog Med Sci 2011 : VEGF stimulated Rap1 activity, phosphorylation of ERK and Akt, cyclin D1 expression and cell proliferation were repressed in HUVECs overexpressing Rap1GAP as compared to empty vector transfected control