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CCND1 — TCF7
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Tetsu et al., Nature 1999
(Colonic Neoplasms) :
Furthermore, expression of a dominant negative form of
TCF in colon-cancer cells strongly
inhibits expression of
cyclin D1 without affecting expression of cyclin D2, cyclin E, or cyclin dependent kinases 2, 4 or 6
Rhee et al., Oncogene 2002
(Carcinoma, Squamous Cell...) :
Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor
LEF/TCF , and
diminished the expression of
cyclin D1 and beta-catenin proteins
Li et al., Genomics 2004
:
The strong binding of E2F1 and NFkappaB is especially noteworthy, because the former
transcription factor is
regulated by
cyclin D1 , a downstream target of beta-catenin/TCF/LEF signaling, whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways
Jung et al., Cancer Res 2004
(Prostatic Neoplasms) :
Because
cyclin D1 is mainly
regulated by
beta-catenin/T-cell factor ( TCF ) , TCF-4 response element was used in a reporter gene transcription assay, demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells
Ho et al., Toxicol Appl Pharmacol 2005
(Lung Neoplasms) :
The increased
cyclin D1 protein level was
induced through activation of the
transcription factor , nuclear factor kB ( NFkappaB ), in the NHBE cells
Sourisseau et al., Mol Cell Biol 2006
:
Regulation of PCNA and
cyclin D1 expression and epithelial morphogenesis by the ZO-1 regulated
transcription factor ZONAB/DbpA
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
WNT-beta-catenin-TCF/LEF signaling
induces upregulation of MYC,
CCND1 , WISP1, FGF20, JAG1 and DKK1 genes ...
WNT-beta-catenin-TCF/LEF signaling
induces upregulation of MYC,
CCND1 , WISP1, FGF20, JAG1 and DKK1 genes
Budhram-Mahadeo et al., Oncogene 2008
(Breast Neoplasms...) :
Proliferation associated Brn-3b
transcription factor can
activate cyclin D1 expression in neuroblastoma and breast cancer cells
Mikheev et al., Breast Cancer Res Treat 2008
:
Consistent with the results of these transient transfection assays, we were unable to demonstrate the expected beta-catenin
dependent ,
TCF/Lef mediated inhibition of
cyclin D1 and c-myc gene transcription in breast cells overexpressing DKK-1
Taurin et al., Am J Physiol Cell Physiol 2008
:
Using the PKA inhibitor PKI or dominant negative TCF-4 mutant, we show that ATP induced
cyclin D1 promoter activation, cyclin D1 protein expression, and proliferation of VSMC are all
dependent on PKA and
TCF activities
Zhang et al., J Biol Chem 2012
(Colonic Neoplasms) :
We find that knockdown of PAX2 inhibits the activity of AP-1, a
transcription factor that
induces cyclin D1 expression, implying that PAX2 induces cyclin D1 through AP-1
Schulze et al., Oncogene 1994
:
Activation of the E2F
transcription factor by
cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1