Lu et al., EMBO J 2004
:
Localization of Tec29 to ring canals is mediated by Src64 and PtdIns ( 3,4,5 ) P3-dependent mechanisms ... In the absence of its PH domain, Tec29 constitutively localizes to ring canals, but still requires Src64 for full activation
Popa-Nita et al., Arthritis Rheum 2008
(Gout) :
MSU crystals induced the phosphorylation and activation of Tec in a Src dependent manner
Roulier et al., Mol Cell 1998
:
Mutants lacking the Drosophila Src homolog Src64 show the same phenotype, and we show that Src64 is required for the localization of Tec29 to the ring canals