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HSF4 — IL2

Text-mined interactions from Literome

Haghighi et al., Immunopharmacology 1992 : Hybridoma suppressor factor ( s ) ( HSF ), secreted by a human thymus hybridoma ( 8E-24 ) established in this laboratory, suppresses Ig as well as IL-2 synthesis by peripheral blood mononuclear cells ( PBMC )
Tomita et al., Immunobiology 1990 : Additionally, HSF did not inhibit the expression of either IL-2R ( p55 ) or TFR by activated T cells in spite of causing the suppression of IL-2 production
Murakami et al., Hybridoma 1988 : Human hybridoma suppressor factor ( HSF ) inhibits IL2 production in addition to suppressing immunoglobulin production ... In this system HSF significantly suppressed PHA induced interleukin 2 ( IL2 ) production of peripheral blood mononuclear cells ( PBMC ) in a dose dependent fashion without inhibiting the proliferative response of CTLL-20 target cells to IL2 ... To investigate the role of HSF induced IL2 suppression in the pokeweed mitogen ( PWM ) antibody synthesis assay, the time course of IgG, IgM, IL1, and IL2 production of PWM stimulated PBMC cultures was examined
Tomita et al., Immunopharmacology 1988 : Here we analysed, further, the mechanism of HSF mediated suppression of Ig and IL-2 production ... We demonstrated that HSF inhibited PWM induced IL-2 production by CD4+ cells but not by CD8+ cells and its suppressive activity on Ig production was totally abrogated by preabsorption with CD4+ cells, but not by CD8+ cells