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CDCA5 — HSD11B2

Text-mined interactions from Literome

Stauffer et al., J Biol Chem 2002 (Cholestasis...) : In contrast, CDCA and DCA both inhibited 11 beta HSD2 with IC ( 50 ) values of 22 and 38 microm, respectively and caused cortisol dependent nuclear translocation and increased transcriptional activity of MR. LCA, the bile acid that most efficiently inhibited 11 beta HSD2, was present at very low concentrations in cholestatic patients, whereas the weak inhibitor CA did not cause MR activation
Morris et al., Endocr Res 1996 (Hypertension) : These results show that both 3 alpha,5B-THP and CDCA are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be involved in the pathology of hypertension