◀ Back to FAS

FAS — RAF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CFLAR-KRT18-KRT8-RAF1 → FAS (increases) Gilbert et al., Mol Cell Biol 2004*
  Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.

Text-mined interactions from Literome

Gilbert et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : c-Flip, along with Raf-1, is part of a K8/K18 immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex
Shin et al., Int J Hematol 2010 : To distinguish between the activation signalling and the death inducing pathway downstream of Fas, we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies induced tyrosine phosphorylation of TCR-proximal proteins, activation of Raf-1/ERK , p38 and JNK, and increased expression of CD69, Fas , and Fas ligand