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FAS — SREBF1

Text-mined interactions from Literome

Gondret et al., J Lipid Res 2001 : Moreover, overexpression of ADD-1/SREBP-1 by adenoviral gene transfer induces FAS in chicken adipocytes, where lipogenesis is normally low
Lacasa et al., J Biol Chem 2001 : Fatty acid synthase (FAS) , a nutritionally regulated lipogenic enzyme, is transcriptionally controlled by ADD1/SREBP1c ( adipocyte determination and differentiation 1/sterol regulatory element binding protein 1c ), through insulin mediated stimulation of ADD1/SREBP1c expression
Wolf et al., Biol Chem 2001 : This finding was confirmed by using a dominant negative form of NF-YA, NF-YAm29, which interferes with the effect of ectopically expressed SREBP-1a on FAS reporter activity
Diraison et al., Biochem J 2004 : Real-time PCR ( TaqMan ) analysis showed that SREBP1c up-regulated the expression of FAS ( fatty acid synthase ; 6-fold ), acetyl-CoA carboxylase-1 ( 2-fold ), as well as peroxisomal-proliferator activated receptor-gamma ( 7-fold ), uncoupling protein-2 ( 1.4-fold ) and Bcl2 ( B-cell lymphocytic-leukaemia proto-oncogene 2 ; 1.3-fold )
Gosmain et al., J Lipid Res 2005 : Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues ... The concomitant measurement of SREBP-1a and SREBP-1c mRNA levels, of mature SREBP-1 protein abundance in nuclear extracts, and of SREBP-1 interaction with target promoters led to the conclusion that SREBP-1 plays a major role in the response of FAS and HKII genes to nutritional regulation in rodents
Chang et al., J Lipid Res 2005 : In addition, overexpression of active SREBP-1 directly stimulated SCD-1 and FAS ... Conversely, adenovirus mediated overexpression of a dominant negative form of SREBP-1 inhibited the KGF effect on FAS and SCD-1 expression ... In summary, we conclude that KGF requires both PI3K and JNK signaling pathways to induce SREBP-1 , which in turn induces SCD-1 and FAS expression in H292 cells
da Silva Xavier et al., J Lipid Res 2006 : Both ChREBP and SREBP-1c were required for the induction of the fatty acid synthase (FAS) promoter by glucose, and chromatin immunoprecipitation ( ChIP ) assay revealed that glucose induced the binding of both ChREBP and SREBP-1c to the FAS promoter without affecting USF2 binding
Ren et al., Biochem Biophys Res Commun 2007 : 25HC3S also decreased SREBP-1 mRNA levels and inhibited the expression of target genes encoding acetyl CoA carboxylase-1 (ACC-1) and fatty acid synthase (FAS)
Hebbachi et al., J Biol Chem 2008 : The mRNA expression of lipogenic genes Scd-1 and Fas is regulated partly by the insulin-sensitive transcription factor SREBP-1c and liver X receptor alpha ( LXRalpha )
Oem et al., J Gen Virol 2008 : We also showed that FAS upregulation by HCV NS2 was SREBP-1 dependent since deleting the SRE sequence in a FAS promoter and expressing a dominant negative SREBP-1 abrogated FAS promoter upregulation by HCV NS2
Pil Hwang et al., Mol Nutr Food Res 2013 : CDCQ strongly inhibited high glucose induced FAS expression by modulating SREBP-1c activation
Hao et al., Am J Physiol Cell Physiol 2013 : Results were as follows : 1 ) IFN-? increased MMC cell lipid deposition, triglyceride content, and p-JAK2, p-STAT1, SREBP-1, and FAS expression ; 2 ) SREBP-1 inhibition prevented FAS upregulation and attenuated IFN-? induced MMC cell lipid deposition and triglyceride content ; 3 ) HMGB1 upregulated SREBP-1 and FAS mRNA and protein levels, which increased lipid deposition in MMC cells