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IL4 — PPARG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Huang et al., Nature 1999
:
Here we show that
interleukin-4 also
induces the expression of
PPAR-gamma and provide evidence that the coordinate induction of PPAR-gamma and 12/15-lipoxygenase mediates interleukin-4 dependent transcription of the CD36 gene in macrophages
Kitamura et al., J Neuroimmunol 2000
:
IL-4 , however,
induced peroxisome proliferator activated receptor (
PPAR)-gamma in cultured microglia
Ricote et al., Horm Res 2000
:
We show that
IL-4 induces the expression of
PPAR-gamma and provide evidence that the coordinate induction of PPAR-gamma and 12/15-lipoxygenase mediates IL-4 dependent transcription of the CD36 gene and down-regulation of iNOS in macrophages
Cunard et al., J Immunol 2002
:
We also demonstrate that
PPARgamma gene expression is up-regulated in T cells by mitogen activation, that it is positively regulated by IL-4 and WY14,643, and that it is
blocked by
anti-IL-4
Chung et al., Mol Pharmacol 2003
:
In this study, the
effects of
PPAR-gamma ligands on production of
IL-4 , a pro-inflammatory cytokine associated with the pathophysiology of allergic diseases, were investigated ... In cotransfected EL-4 T cells,
PPAR-gamma also
inhibited the activation of the
IL-4 promoter at multiple NF-AT sites in a ligand dependent manner
Hua et al., Cytokine 2004
:
IL-4 alone and IL-4 added to the differentiation cocktail
had no effect on adipocyte formation or
PPARgamma expression
Paintlia et al., J Immunol 2006
(Demyelinating Diseases...) :
Next, EMSA, immunoblots, and transient cotransfection studies with reporter plasmids ( pNF-kappaB-Luc and pTK-PPREx3-Luc ) and 12/15-LOX small interfering RNA revealed that
IL-4 induced
PPAR-gamma activation antagonizes NF-kappaB transactivation in Cyt-Mix treated astrocytes
Stewart et al., BMC molecular biology 2007
:
Interleukin-4 inhibition of interleukin-1 induced expression of matrix metalloproteinase-3 (MMP-3) is
independent of lipoxygenase and
PPARgamma activation in human gingival fibroblasts ... Activators of peroxisome proliferator activated receptor-gamma ( PPARgamma ) have been shown to inhibit cytokine induced expression of MMPs in other cell types, and
IL-4 has been shown to
activate PPARgamma by stimulating production of ligands through the lipoxygenase pathway ... The objective of this study was to determine whether the suppressive
effects of
IL-4 on the IL-1 induced expression of MMP-3 involve activation of lipoxygenase and/or
PPARgamma