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CALM3 — GNRH1

Text-mined interactions from Literome

Xie et al., Mol Endocrinol 2008 : Furthermore, association of Pyk2 and Cam may be required to mediate the effects of calcium on Pyk2 phosphorylation and subsequent activation of ERKs by GnRH
Melamed et al., J Neuroendocrinol 2012 : Gonadotrophin gene expression is also regulated by GnRH induced CaM dependent kinases (CaMKs) ; CaMKI is able to derepress the histone deacetylase-inhibition of ß-subunit gene expression, whereas CaMKII appears to be essential for the GnRH-activation of all three subunit genes
Simpson et al., Endocr Res 1987 : Cellular calmodulin content increased in response to gonadotropin releasing hormone (GnRH) , as did the concentration of cGMP, while both responses were prevented by the administration of inhibin
Ojeda et al., Brain Res 1988 : Similarly to PGE2, the stimulatory effect of the Ca2+ ionophore A 23187 on LHRH release was not affected by inhibition of calmodulin activity ... The results indicate that : ( a ) the stimulatory effect of PGE2 on LHRH release involves mobilization of intracellular Ca2+ but not the participation of calmodulin ; ( b ) the formation of PGE2 itself is calmodulin dependent ; ( c ) PGE2 stimulates cAMP formation through a calmodulin dependent mechanism that requires translocation of intracellular ( membrane ? )
Kile et al., Am J Physiol 1988 : Calmodulin antagonist effects on GnRH and secretogogue induced release of bovine LH ... Primary calf anterior pituitary cell cultures ( 3 X 10 ( 5 ) /well ) were treated with either LH secretogogue ( GnRH, 100 ng/ml ; A23187, 2.5 microM ; theophylline, 1 mM ; prostaglandin E2, 1 microM ; estradiol, 25 ng/ml ; or KCl, 25 mM ; final concentrations ) or secretogogue plus CaM inhibitor in 1 ml Hanks ' balanced salt solution plus 10 mM N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid for 6 h. Significant ( P less than 0.01 ) inhibition of GnRH- and A23187 stimulated LH release was obtained with calmidazolium ( CMZ ; 1-10 nM ) and N- ( 6-aminohexyl ) -5-chloro-1-naphthalenesulfonamide ( W-7 ; 1-10 microM )
Sullivan et al., Biochem J 1985 : Effects of calmodulin and lipoxygenase inhibitors on LH ( lutropin ) - and LHRH ( luliberin ) -agonist stimulated steroidogenesis in rat Leydig cells
Waters et al., Neuroendocrinology 1998 : Calcium/calmodulin dependent protein kinase II involvement in release of gonadotropin releasing hormone