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JUN — TCF12
Text-mined interactions from Literome
Chen et al., Mol Carcinog 1999
:
Our previous studies have indicated that UVB induced c-fos expression may play a key role in UVB induced activation of the activator protein-1
transcription factor and EGCG inhibited, UVB induced
activation of
AP-1 in HaCaT cells
Famulski et al., Cell Death Differ 1999
:
We propose that ( i ) the up-regulation of an acidic nuclease activity is governed by a regulatory pathway different from that responsible for AP-1 factor induction, caspases activation and intracellular acidification, and ( ii ) activation of an acidic nuclease does not cause any deleterious effects when
AP-1 transcription factor induction , caspases activation and intracellular acidification are down-regulated
Troussard et al., Oncogene 2000
(Glioblastoma) :
The integrin linked kinase (ILK) induces an invasive phenotype via
AP-1 transcription factor dependent upregulation of matrix metalloproteinase 9 (MMP-9)
Sodhi et al., J Interferon Cytokine Res 2002
:
Additionally, phosphorylation of JNK and
activation of the
transcription factor ,
c-Jun , were also noted in response to MCP-1 treatment
Ventura et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
The JNK signal transduction pathway is therefore essential for
AP-1 transcription factor regulation in cells exposed to TNF
Chen et al., Arterioscler Thromb Vasc Biol 2003
(Arteriosclerosis) :
Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited
transcription factor nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions, respectively ) but only GBE could
inhibit the TNF-alpha stimulated
activator protein 1 activation ( 45.1 % inhibition, P < 0.05 )
Kinser et al., J Toxicol Environ Health 2004
(Inflammation) :
c-Fos, Fra-,
c-Jun , and JunB, components of the activator protein-1 (AP-1) transcription factor complex, were
induced by DON as well as another
transcription factor , NR4A1
Hwang et al., FEBS Lett 2005
:
AP-1 activation suppressed the expression of Sox-9, a major
transcription factor regulating type II collagen expression
Sahambi et al., Birth Defects Res A Clin Mol Teratol 2006
(Abnormalities, Drug-Induced) :
We hypothesize that oxidative stress and
activation of a redox-sensitive
transcription factor ,
activator protein-1 (AP-1) , are early indicators of embryonic stress in response to a teratogenic insult ... We hypothesize that oxidative stress and
activation of a redox-sensitive
transcription factor ,
activator protein-1 (AP-1), are early indicators of embryonic stress in response to a teratogenic insult
Tu et al., Am J Physiol Cell Physiol 2007
:
Involvement of oxidants and
AP-1 in angiotensin II-activated NFAT3
transcription factor
Smart et al., Hepatology 2006
(Carbon Tetrachloride Poisoning...) :
JunD is a profibrogenic
transcription factor regulated by
Jun N-terminal kinase independent phosphorylation
Weinberg et al., Neuroscience 2007
:
Differential basal and stress induced expression patterns of the fra-2 and c-fos genes are likely to have important functional consequences for
AP-1 transcription factor dependent
regulation of neural plasticity
Lin et al., Inflamm Bowel Dis 2008
(Crohn Disease) :
Probiotic L. reuteri suppressed TNF transcription by inhibiting activation of MAP kinase
regulated c-Jun and the
transcription factor ,
AP-1
Salisbury et al., Mol Endocrinol 2009
:
Together, these results indicate that GnRH regulation of
Jun transcription
requires a functional interaction between
TCF/LEF and beta-catenin and that alteration of either impacts expression of JUN downstream targets such as Cga
Jung et al., Biofactors 2008
:
Matrine
inhibited PMA induced activation of the
AP-1 promoter, an important nuclear
transcription factor in MMP-1 expression
Hsieh et al., Journal of neuroinflammation 2010
(MAP Kinase Signaling System) :
ROS production leads to
activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and
c-Jun-N-terminal kinase (JNK) and then activation of the NF-?B
transcription factor
Chae et al., Biosci Biotechnol Biochem 2011
:
And, it
inhibited DNA binding activity of
activator protein-1 (AP-1) , a
transcription factor of MMP-1 and downstream of ERK and JNK
Hwang et al., Arthritis Res Ther 2012
(Arthritis, Rheumatoid) :
Importantly, the preferential induction of IL-34 rather than M-CSF by TNFa in RAFLS was mediated by the
transcription factor nuclear factor kappa B ( NF-?B ) and
activation of
c-Jun N-terminal kinase (JNK)
Hattori et al., Am J Physiol 1993
(Acute-Phase Reaction...) :
These findings demonstrate the complexity of
AP-1 hepatic
transcription factor responses to humoral regulators with direct hepatocellular effects
Erkel et al., J Antibiot (Tokyo) 1996
:
In reporter gene assays nidulal ( 1 ) preferentially activated the
transcription factor complex
AP-1 mediated expression of secreted alkaline phosphatase in COS-7 cells
Manna et al., J Immunol 1998
:
TNF induced
activation of another nuclear
transcription factor ,
AP-1 , was suppressed by IL-13
Chen et al., J Biol Chem 1998
:
The effects of UVB irradiation on
transcription factor activator protein-1 (AP-1) DNA binding and
AP-1 transactivation were studied in a human keratinocyte cell line, HaCaT