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IDO1 — NOS2

Text-mined interactions from Literome

Däubener et al., Adv Exp Med Biol 1999 : We were able to show that the IL-1 and TNF-alpha mediated inhibition of IFN-gamma induced IDO activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase
Penberthy et al., Curr Drug Metab 2007 (Autoimmune Diseases) : Chronic elevation of TNFalpha leading to necrotic events by NAD depletion in autoimmune disease likely occurs via combination of persistent IDO activation and iNOS-peroxynitrate activation of PARP1 both of which deplete NAD
Kujundzić et al., Immunol Lett 2008 : Inhibition of indoleamine-2,3-dioxygenase , the rate limiting enzyme of TRP catabolism, by 1-methyl-l-tryptophan ( 1-mTRP ) down regulated both iNOS gene transcription and NO production
Jackman et al., Naunyn Schmiedebergs Arch Pharmacol 2011 (Disease Models, Animal...) : Mice were pre treated with vehicle, the Ido1 inhibitor, 1-methyl-D-tryptophan ( 1-MT ; 50 mg/kg i.p. ) or the inducible nitric oxide synthase ( Nos2 ) inhibitor , aminoguanidine ( AG, 100 mg/kg i.p. ) ... Inhibition of Nos2 with AG also did not affect Ido activity or outcome following stroke
Darcy et al., PloS one 2011 (Sepsis) : Increased IDO activity ( measured by the kynurenine to tryptophan [ KT ] ratio in plasma ) causes T-cell apoptosis, vasodilation and nitric oxide synthase inhibition
LaPointe et al., Hypertension 1998 : We next studied the involvement of the PLA2 inhibitor ONO-RS-082 ( ONO ) and the COX inhibitor INDO in IL regulation of iNOS