◀ Back to CA2

CA2 — CD2

Text-mined interactions from Literome

Kochegarov et al., Biochemistry (Mosc) 2000 : In most cases, Cd2+ itself induces release of Ca2+ from the CTC stained calcium pool ; the more effective Cd2+ is, the less the following ionomycin or BHQ responses occur
DelPrincipe et al., J Physiol 2000 : The Ca2+ influx signal arising from L-type Ca2+ current activation was usually blocked by 50 microM Cd2+ ... However, the Ca2+ influx signal elicited by the Na+ current activation protocol was only curtailed to 56.4 +/- 28.2 % by 100 microM Ni2+ but was reduced to 17.9 +/- 15.1 % by 50 microM Cd2+ and consistently eliminated by 5 mM Ni2+
Hasselgren et al., J Biol Inorg Chem 2001 : Cd2+ binds to the two metal binding sites in a sequential manner to produce a very active Cd2+ substituted derivative, particularly in the presence of Ca2+ ( 53 % and 90 %, respectively, relative to the activities of the native form in terms of kcat/Km under the same conditions )
Richter et al., J Physiol 2003 : Acid evoked Ca2+ responses were blocked by Ba2+ ( 2 mM ) and Cd2+ ( 500 microM ), suggesting that acid responses are generated by Ca2+ influx through depolarization gated Ca2+ channels
Arens et al., Can J Physiol Pharmacol 1992 : Ni2+ had similar effects as the organic Ca2+ entry blockers while Cd2+ reduced both the [ Ca2+ ] o decreases as well as the subsequent overshoots
Ledbetter et al., Blood 1991 (Leukemia-Lymphoma, Adult T-Cell) : Thus, CD4 regulates CD3/Ti signal transduction in T-ALL cells through the tyrosine phosphorylation of substrates whereas CD2 may regulate [Ca2+ ] i signal transduction through a separate mechanism
Deusch et al., J Immunol 1990 : Here we examine the role of CD4, CD8, CD2 , and CD45 in the regulation of intracellular Ca2+ levels in mature and immature thymocytes
Fuchs et al., J Physiol 1990 : 3. This inward current was a Ca2+ current since it required Ca2+ in the external medium, could also be carried by Ba2+, and was blocked reversibly by 5 mM-Co2+ and by Ni2+ and Cd2+ at micromolar concentrations
Ghnaya et al., Chemosphere 2007 : Effects of Cd2+ on K+, Ca2+ and N uptake in two halophytes Sesuvium portulacastrum and Mesembryanthemum crystallinum : consequences on growth
Yeh et al., J Exp Bot 2007 (MAP Kinase Signaling System) : Using a Ca2+ indicator, it was demonstrated that Cd2+ and Cu2+ induce Ca2+ accumulation in rice roots ... The Cd2+- and Cu2+ induced MAP kinase activation required the involvement of Ca2+ dependent protein kinase (CDPK) and phosphatidylinositol 3-kinase ( PI3 kinase ) as shown by the inhibitory effect of a CDPK antagonist, W7, and a PI3 kinase inhibitor, wortmannin, respectively
Moreno-Sánchez et al., Int J Biochem 1991 : 1. We studied the effect of verapamil, nitrendipine, 3',4'-dichlorobenzamil ( DCB ) and Cd2+ on the increase in cytosolic free Ca2+ ( [ Ca2+ ] c ) and the rate of O2-uptake induced by depolarization of isolated rat cardiac myocytes with veratridine
Bartlett et al., Philos Trans R Soc Lond B Biol Sci 2008 : Cd2+ competitively blocks the binding of Ca2+ to its functional site with 10- to 30-fold higher affinity, but does not influence the binding of Mn2+ to its high-affinity site
Jones et al., Protein Sci 2008 : To understand these processes, we have successfully introduced a novel Ca2+ binding site into the non-Ca2+ dependent cell adhesion protein CD2 using our criteria that are specifically tailored to the structural and functional properties of the protein environment and charged adhesion surface
Shah et al., Brain Res 1991 : In addition to this, Cd2+ also stimulates a rapid release of Ca2+ ( t1/2 = 0.5 min ) from the microsomes in a dose dependent manner
Yeh et al., Basic Clin Pharmacol Toxicol 2009 : The effect of Cd2+ on intracellular free-Ca2+ levels ( [ Ca2+ ] ( i ) ) and viability in Madin Darby canine kidney cells was explored ... Cd2+ induced Ca2+ release was not altered by inhibition of phospholipase C ... Collectively, this study shows that Cd2+ induced a [ Ca2+ ] ( i ) increase in Madin Darby canine kidney cells via evoking Ca2+ entry through non-selective Ca2+ channels, and releasing stored Ca2+ from endoplasmic reticulum and mitochondria in a phospholipase C-independent manner
Nasu et al., Gen Pharmacol 1990 : 2. Cd2+ ( 2 x 10 ( -6 ) M ) which had no effect on the tissue ATP concentration, inhibited La3+ resistant residual Ca2+ binding at the high and low affinity site ... Cd2+ ( 10 ( -5 ) M ) which decreased the tissues ATP concentration, markedly inhibited Ca2+ binding at the low affinity site ... 4. These findings suggest that Cd2+ at low concentration may inhibit Ca2+ influx through Ca2+ channel at surface membrane while at high concentrations ( greater than 10 ( -5 ) M ), Cd2+ would inhibit the accumulation of Ca2+ into low affinity sites relating to energy metabolism at mitochondria
Constanti et al., Pflugers Arch 1985 : The inward currents were maintained when external Ca2+ was replaced by Ba2+, and were blocked by Cd2+ , suggesting that Ca2+ was the principal charge carrier
Verbost et al., J Biol Chem 1989 : As a result Cd2+ disturbs intracellular Ca2+ homeostasis and may increase cytosolic Ca2+ ( Ca2+i ) to toxic levels
Yamaguchi et al., Chem Pharm Bull (Tokyo) 1989 : Regucalcin ( 2.0 microM ) did not enhance the effect of V5+ and Cd2+ on Ca2+-ATPase activity
Nunes et al., J Cell Biochem 1989 : We investigated the action of cholera toxin on the intracellular ionized calcium [Ca2+ ] i increase induced by anti-CD2 and anti-CD3 monoclonal antibodies in the leukemic human T-cell line Jurkat ... All together, these results suggest that cholera toxin acts on substrates, possibly G proteins, that could regulate the [Ca2+ ] i increase induced by anti-CD2 and anti-CD3 mAbs in Jurkat cells ... In addition, the present study demonstrated that the rise in cellular cAMP partially inhibits the [Ca2+ ] i increase induced by anti-CD2 and anti-CD3 mAbs
Belian et al., Neirofiziologiia 1989 : Cd2+ ( 2 mM ) did not affect the cAMP induced current and [Ca2+ ] in increase
Böhme et al., Biochim Biophys Acta 1987 : The high-affinity Ca2+-ATPase was competitively inhibited by La3+ and Cd2+ ; we suggest that this high-affinity enzyme mediates the release of Ca2+ from D. discoideum cells
Flik et al., Arch Toxicol 1987 : Cd2+ inhibits Ca2+- and CaM dependent PDE in a competitive way
Verbost et al., J Membr Biol 1988 : ATP-driven Ca2+-transport in basolateral membrane (BLM) vesicles was inhibited by Cd2+ with an I50 value of 3.0 nM at 0.25 microM free Ca2+, using EGTA, HEEDTA and NTA to buffer Ca2+ and Cd2+ concentrations
Toury et al., Toxicol Appl Pharmacol 1985 : In mitochondria, a Cd2+ activation of phospholipase A2 and/or a Ca2+-sensitive protease is a unique possibility, since Ca2+ accumulation was prevented by cytosolic Cd2+
Suszkiw et al., Brain Res 1984 : Pb2+ ( Ki approximately 1.1 microM ) and Cd2+ ( Ki approximately 2.2 ) competitively block the K+-evoked influx of 45Ca2+ through the ` fast ' calcium channels in synaptosomes ... Cd2+ inhibits Ca2+ binding at all concentrations tested ( 1-50 microM ) and reduces the Pb2+ induced Ca2+ binding to organelles
Guven et al., Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1995 : The transgene response to Cd2+ is strongly inhibited by Ca2+ ions ; furthermore, Ca2+ reduces the net accumulation of Cd2+ by worms
Cao et al., Environ Health Perspect 1995 : In this study we investigated the effects of competing trace metals and Ca2+ on Cd(II) , Pb ( II ), and Cu ( II ) complexation by humic acid extracted from groundwater in Orange County, California
Cain et al., FEBS Lett 1995 : We now show that Cd2+ , Hg2+, dichloroisocoumarin ( DCI, a serine protease inhibitor ) and N-ethylmaleimide ( NEM ) block both Mg2+ and Ca2+/Mg ( 2+ ) -dependent processes
Parekh et al., J Physiol 1993 : The latter was sensitive to external Ca2+ and was blocked by Cd2+
McDonald et al., Arch Biochem Biophys 1996 : The Ca2+ response following fluid flow stimulation was blocked by 300 microM Cd2+ , a specific blocker of Ca2+ channels, demonstrating an extracellular source of Ca2+
Long et al., Toxicol Appl Pharmacol 1997 (Bone Neoplasms...) : This work was conducted to determine the effect of Cd2+ on cytosolic free Ca2+ ( [ Ca2+ ] i ) levels, characterize the activation and/or inhibition of PKC by Cd2+ and Ca2+, and measure the effect of Cd2+ on collagen synthesis in ROS 17/2.8 cells
Janiak et al., J Physiol Pharmacol 1997 : 100 microM Cd2+ inhibited the initial rise in [Ca2+ ], however, the inhibition did not correlate with degree of inhibition of Ca2+ current
Cheng et al., Eur J Neurosci 1998 (Synaptic Transmission) : High K+-induced increase in [Ca2+ ] i was blocked by Ca2+-free solution and Cd2+ suggesting that Ca2+ entry responsible for the depolarization evoked increase in [Ca2+ ] i occurred through voltage dependent Ca2+ channels
Gobbi et al., Naunyn Schmiedebergs Arch Pharmacol 1998 : The [ 3H ] 5-HT release induced by ( + ) -norfenfluramine was partly ( about 50 % ) but significantly Ca2+ dependent , and it was also markedly ( 68 % ) inhibited by Cd2+ , a non-specific blocker of voltage dependent Ca2+ channels, suggesting that the Ca2+ dependent release is mediated by entry of Ca2+ into the synaptosomes through these channels