Gene interactions and pathways from curated databases and text-mining

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CA2 — CRH

Text-mined interactions from Literome

Rossant et al., Endocrinology 1999 : These data demonstrate that cAMP-, Ca2+- , and MAP kinase dependent signaling pathways are activated by stimulation of CRF-1 and CRF-2alpha receptors
Carlson et al., Anticancer Res 2001 (Calcium Signaling...) : Calcium-sensitive fluorescence measurements were used to examine the effect of CRH on intracellular Ca2+ signaling
Spada et al., J Clin Endocrinol Metab 1990 (Adenoma...) : Inhibition of basal and corticotropin releasing hormone stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin secreting pituitary adenomas
Widmaier et al., Am J Physiol 1988 : The increase in CRF secretion at low glucose ( 0.55 or 1.38 mM ) was Ca2+ dependent and completely reversible
Kiang et al., Chin J Physiol 1994 (Carcinoma, Squamous Cell...) : This suggests that a CRF induced increase in [ Ca2+ ] i mediates the increase in PKC activity
Kiang et al., Eur J Pharmacol 1995 : alpha-Helical CRF- ( 9-41 ), a synthetic CRF receptor antagonist, and pertussis toxin also blocked the increase in [ Ca2+ ] i induced by the two peptides
Kuryshev et al., Endocrinology 1996 : Tetrodotoxin also had no effect on spontaneous or CRH induced cytosolic Ca2+ levels ... The combination of nifedipine and omega-agatoxin-IVA abolished the CRH induced rise in Ca2+ , but did not abolish the membrane depolarization
Lee et al., J Physiol 1997 (Ion Channel Gating) : Both the CRH induced depolarization and [ Ca2+ ] i elevation could be mimicked by extracellular application of the adenylate cyclase activator forskolin or the membrane-permeable cAMP analogue, 8- ( 4-chlorophenylthio ) -adenosine-3',5'-cyclic monophosphate ( 8-CPT-cAMP )
Fazal et al., FEBS Lett 1998 (Melanoma) : Corticotropin releasing factor (CRF) induces a rapid, within seconds, and dose dependent increase in the intracellular Ca2+ in both human and hamster melanoma cells