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CA2 — CRH
Text-mined interactions from Literome
Rossant et al., Endocrinology 1999
:
These data demonstrate that cAMP-,
Ca2+- , and MAP kinase dependent signaling pathways are
activated by stimulation of
CRF-1 and CRF-2alpha receptors
Carlson et al., Anticancer Res 2001
(Calcium Signaling...) :
Calcium-sensitive fluorescence measurements were used to examine the
effect of
CRH on intracellular
Ca2+ signaling
Spada et al., J Clin Endocrinol Metab 1990
(Adenoma...) :
Inhibition of basal and
corticotropin releasing hormone stimulated adenylate cyclase activity and cytosolic
Ca2+ levels by somatostatin in human corticotropin secreting pituitary adenomas
Widmaier et al., Am J Physiol 1988
:
The increase in
CRF secretion at low glucose ( 0.55 or 1.38 mM ) was
Ca2+ dependent and completely reversible
Kiang et al., Chin J Physiol 1994
(Carcinoma, Squamous Cell...) :
This suggests that a
CRF induced increase in [
Ca2+ ] i mediates the increase in PKC activity
Kiang et al., Eur J Pharmacol 1995
:
alpha-Helical
CRF- ( 9-41 ), a synthetic CRF receptor antagonist, and pertussis toxin also
blocked the increase in [
Ca2+ ] i induced by the two peptides
Kuryshev et al., Endocrinology 1996
:
Tetrodotoxin also had no effect on spontaneous or
CRH induced cytosolic
Ca2+ levels ... The combination of nifedipine and omega-agatoxin-IVA abolished the
CRH induced rise in
Ca2+ , but did not abolish the membrane depolarization
Lee et al., J Physiol 1997
(Ion Channel Gating) :
Both the
CRH induced depolarization and [
Ca2+ ] i elevation could be mimicked by extracellular application of the adenylate cyclase activator forskolin or the membrane-permeable cAMP analogue, 8- ( 4-chlorophenylthio ) -adenosine-3',5'-cyclic monophosphate ( 8-CPT-cAMP )
Fazal et al., FEBS Lett 1998
(Melanoma) :
Corticotropin releasing factor (CRF) induces a rapid, within seconds, and dose dependent increase in the intracellular
Ca2+ in both human and hamster melanoma cells