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CA2 — F2R
Text-mined interactions from Literome
Oshiro et al., Life Sci 2002
(Calcium Signaling) :
An increase in [
Ca2+ ] i was also
induced by an agonist peptide for PAR-2 ( SLIGRL-NH2, 0.001-10 microM ) but not by thrombin ( 3 units/ml, an activator for
PAR-1 , PAR-3 or PAR-4 )
Homoncik et al., Blood Coagul Fibrinolysis 2003
:
In summary,
Ca(II)3 ( 3,5-DIPS ) 6, a new calmodulin dependent nitric oxide synthase activator, decreases P-selectin expression of human platelets in
response to
thrombin receptor activation
Boire et al., Cell 2005
(Breast Neoplasms...) :
Further, we show that the matrix metalloprotease, MMP-1, functions as a protease agonist of PAR1 cleaving the receptor at the proper site to generate
PAR1 dependent
Ca2+ signals and migration
Jardin et al., Biochem J 2007
:
Desensitization of
PAR-1 and PAR-4 or pre-treatment with the PAR-1 and PAR-4 antagonists SCH 79797 and tcY-NH2 reduced Ca2+ mobilization induced by thrombin, and depletion of the DTS after desensitization or blockade of PAR-1 and PAR-4
had no significant effect on
Ca2+ release stimulated by thrombin through the GPIb-IX-V receptor
Mari et al., J Biol Chem 1994
:
A synthetic
thrombin receptor agonist peptide (TRP) of 7 residues ( SFLLRNP ) was found to be as effective as thrombin for [ Ca2+ ] i mobilization, and both agonists
induced Ca2+ release exclusively from internal stores
Shankar et al., J Biol Chem 1994
:
Recent studies have shown that the synthetic peptides SFL LRN and SFL LRN PND KYEPF ( thrombin receptor activating peptides ( TRAP ) ) derived from the deduced sequence of the new amino terminus of the cleaved thrombin receptor can mimic
thrombin receptor activation, act as full agonists for platelet activation, and
induce prostaglandin I2 production as well as cytosolic
Ca2+ increase in human umbilical vein endothelial cells ( HUVEC )
Mathias et al., Am J Physiol 1998
(Second Messenger Systems) :
The effect of inositol 1,4,5-trisphosphate ( IP3 ) receptor blockade on platelet derived growth factor ( PDGF ), fibroblast growth factor ( FGF ), endothelin-1 (ET-1), or
alpha-thrombin receptor mediated intracellular
Ca2+ ( Ca2+i ) release was examined using fura 2 microspectrofluorometry in single Chinese hamster ovary cells and myoblasts