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C3 — IL8

Pathways - manually collected, often from reviews:

• Reactome Reaction: C3 → IL8 (reaction) Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994

Text-mined interactions from Literome

Matata et al., Ann Thorac Surg 2000 (Inflammation) : Complement C3a and elastase levels were rapidly increased upon the institution of CPB, and this was followed by increases in IL-8 , TNF-alpha, and sE-selectin
Ernst et al., J Clin Immunol 1986 (Acquired Immunodeficiency Syndrome) : In particular, we found a transient increase in C3b receptor mediated monocyte activation in ARC patients ; no influence of therapy on the otherwise intact LPS induced interleukin-1 production in vitro ; in some patients a transient corrective influence on the high pretherapeutic immunoglobulin secretion of B cells and their nonresponsiveness to pokeweed mitogen ; low T-cell responses to soluble antigens and alloantigens, which were partially restored during rIL-2 treatment in ARC patients and in one AIDS patient ; defective NK activity in PBMC of two AIDS patients, which was found to be restored when measured at the end of rIL-2 therapy ; and a rather constant phenotypic pattern of PBMC in each patient during therapy except for the decreasing proportion of OKT9 positive lymphocytes in AIDS patients, the increasing proportion of Leu8-Leu3a+ lymphocytes in all patients, and in particular, the transient significant decrease in the Leu7+/OKT3+ ratio, which pretherapeutically was very high in AIDS patients ( 0.78 +/- 0.21 ) and high in ARC patients ( 0.48 +/- 0.06 ) as compared to healthy controls ( 0.18 +/- 0.08 )