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REL — RELA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
Complex of NFKB1-RELA-RELB-REL-NFKB2
Nonaka et al., Oncogene 2005
-
IRef Bind Interaction:
Complex of RELA-PAPOLA-MAP3K8-REL
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of REL-NFKB2-MAP3K14-RELA
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 25 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 13 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 16 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of FBXW7-NFKB2-REL-MAP3K14-USP2-RELA-IKBKG-IKBKB
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of IKBKB-IKBKAP-REL-NFKBIA-IKBKG-MCM5-NFKB2-MCM7-RELA
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of REL-RELA
Whiteside et al., EMBO J 1997
-
IRef Bind Interaction:
Complex of 21 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of RELB-REL-TNIP2-NFKB1-RELA-NFKBIA-NFKB2-IKBKG-NFKB1
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of RELA-PAPOLA-REL-TNIP2
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Biogrid Interaction:
REL
—
RELA
(physical association, affinity chromatography technology)
Hansen et al., Mol Cell Biol 1994*
-
IRef Biogrid Interaction:
REL
—
RELA
(direct interaction, two hybrid)
Liss et al., J Virol 2002*
-
IRef Biogrid Interaction:
REL
—
RELA
(direct interaction, pull down)
Liss et al., J Virol 2002*
-
IRef Biogrid Interaction:
REL
—
RELA
(direct interaction, pull down)
Hansen et al., Mol Cell Biol 1994*
-
IRef Biogrid Interaction:
REL
—
RELA
(physical association, affinity chromatography technology)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM NFKB1-NFKB2-REL-RELA-RELB complex:
NFKB1-NFKB2-REL-RELA-RELB complex complex (NFKB1-NFKB2-REL-RELA-RELB)
Nonaka et al., Oncogene 2005
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2):
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2):
TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) complex (CHUK-FBXW7-IKBKB-IKBKG-MAP3K14-NFKB2-REL-RELA-SEC16A-USP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1):
TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) complex (ANKRD28-BTRC-CHUK-CUL1-IKBKE-NFKB2-PPP6C-REL-RELA-PPP6R1-PPP6R2-SKP1)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM REL-MAP3K8-RELA-TNIP2-PAPOLA complex:
REL-MAP3K8-RELA-TNIP2-PAPOLA complex complex (MAP3K8-PAPOLA-REL-RELA-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex:
CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex complex (CHUK-COPB2-IKBKG-NFKB1-NFKB2-NFKBIA-NFKBIE-REL-RELA-SPAG9-TNIP1-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I):
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex 5:
TNF-alpha/NF-kappa B signaling complex 5 complex (CD3EAP-CHUK-CUL1-FBXW11-IKBKB-IKBKG-IQGAP2-KPNA2-LRPPRC-MCC-MTIF2-NFKB1-NFKB2-NFKBIB-PDCD2-POLR1A-POLR1B-POLR1D-POLR1E-POLR2H-POLR2L-RASAL2-REL-RELA-SKP1)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM IKB(epsilon)-RELA-cREL complex:
IKB(epsilon)-RELA-cREL complex complex (NFKBIE-REL-RELA)
Whiteside et al., EMBO J 1997
-
MIPS CORUM IKB(beta)-RELA-cREL complex:
IKB(beta)-RELA-cREL complex complex (NFKBIB-REL-RELA)
Whiteside et al., EMBO J 1997
-
MIPS CORUM IKB(alpha)-RELA-cREL complex:
IKB(alpha)-RELA-cREL complex complex (NFKBIA-REL-RELA)
Whiteside et al., EMBO J 1997
-
IRef Corum Interaction:
Complex of REL-NFKBIE-RELA
(association, anti bait coimmunoprecipitation)
Whiteside et al., EMBO J 1997
-
IRef Corum Interaction:
Complex of NFKB1-RELB-NFKB2-REL-RELA
(association, electrophoretic mobility shift assay)
Nonaka et al., Oncogene 2005
-
IRef Corum Interaction:
Complex of RELA-NFKBIA-REL-NFKBIA-RELA-REL
(association, anti bait coimmunoprecipitation)
Whiteside et al., EMBO J 1997
-
IRef Corum Interaction:
Complex of MAP3K8-TNIP2-REL-PAPOLA-RELA
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 11 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 26 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of REL-NFKBIB-REL-RELA-RELA-NFKBIB
(association, anti bait coimmunoprecipitation)
Whiteside et al., EMBO J 1997
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Dip Interaction:
REL
—
RELA
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of RELA-REL-NFKB1-RELA-REL-RELA-NFKB1-NFKB1-REL
(in vivo)
Hansen et al., Mol Cell Biol 1994*
-
IRef Hprd Interaction:
RELA
—
REL
(in vitro)
Hansen et al., EMBO J 1992*, Hansen et al., Mol Cell Biol 1994*, Beg et al., Oncogene 1994*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Scheinman et al., Mol Cell Biol 1993*
-
IRef Hprd Interaction:
Complex of 170 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 101 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 290 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 626 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of COMMD1-RELA-NFKB2-NFKB1-REL-RELB
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of RELB-NFKB1-NFKB2-REL-SIN3A-RELA-BCL3
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of RELA-REL-COMMD1
(association, anti bait coimmunoprecipitation)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
RELA
—
REL
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
REL
—
RELA
(physical association, two hybrid)
Yang et al., Oncogene 1999*
-
IRef Intact Interaction:
Complex of BCL3-NFKB1-NFKB2-REL-SIN3A-RELA-NFKB2-RELB
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Ophid Interaction:
REL
—
RELA
(aggregation, confirmational text mining)
Xu et al., Virology 1995*
-
IRef Ophid Interaction:
REL
—
RELA
(aggregation, confirmational text mining)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Ophid Interaction:
REL
—
RELA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Silverman et al., Genes Dev 2000
:
Remarkably, this Drosophila
IkappaB kinase complex is not
required for the activation of the
Rel proteins Dif and Dorsal through the Toll signaling pathway, which is essential for antifungal immunity and dorsoventral patterning during early development ... Thus, a yet to be identified
IkappaB kinase complex must be
required for
Rel protein activation via the Toll signaling pathway
Haddad et al., J Pharmacol Exp Ther 2002
(Inflammation...) :
Whereas selective inhibition of PDEs 1, 3, and 4, by the action of 8-methoxymethyl-3-isobutyl-1-methylxanthine, amrinone, and rolipram, respectively, exhibited a tendency to augment the translocation of NF-kappaB ( 1 ) ( p50 ), RelA ( p65 ), RelB ( p68 ), and
c-Rel ( p75 ), selective blockade of PDE 5, 6, and 9, by the action of 4- [ [ 3',4'- ( methylenedioxy ) benzyl ] amino ] -6-methoxyquinazoline and zaprinast,
attenuated lipopolysaccharide-endotoxin (LPS) mediated
NF-kappaB translocation
Szabo et al., Frontiers in bioscience : a journal and virtual library 2002
:
Activation of
NF-kappa B , however, is
regulated at multiple levels including I-kappa B degradation, nuclear translocation, and by interaction of NF-kappa
B/Rel with other transcription factors
Antonsson et al., Mol Cell Biol 2003
:
Our results suggest that CaM binds c-Rel and
RelA after their release from I kappa B and can
inhibit nuclear import of
c-Rel while letting RelA translocate to the nucleus and act on its target genes
Monaco et al., Proc Natl Acad Sci U S A 2004
(Arteriosclerosis...) :
We found that
NF-kappa B is activated in these cells and that this activity
involves p65, p50, and
c-Rel but not p52 or RelB
Ravi et al., Drug Resist Updat 2004
(Neoplasms) :
NF-kappaB may be
inhibited by targeting either the apical signaling proteins responsible for its activation in specific types of cancer, the downstream kinases ( IkappaB kinase and casein kinase 2 ) at which NF-kappaB activating signaling pathways converge, the proteasome mediated degradation of the inhibitor of kappaB ( IkappaB ) proteins, or the transcriptional activity of
Rel proteins
Iwamoto et al., Tohoku J Exp Med 2005
(Body Weight...) :
Supershift assays with specific antibodies revealed that p50, but not p52, p65, Rel B, or
c-Rel , may be
involved in the activation of
NF-kappaB , though the component primarily responsible for the increase could not be determined
Thornburg et al., Oncogene 2006
(Lymphoma) :
The LMP1 mediated activation of
NF-kappaB may
contribute to the specific activation of
c-Rel and lead to the increased development of lymphoma in the LMP1 transgenic mice
Ballard et al., Cell 1990
:
v-Rel , but not nontransforming v-Rel mutants, binds to the kappa B enhancer and
inhibits NF-kappa B-activated transcription from the IL-2 receptor alpha promoter and HIV-1 LTR