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MCAT — SETD2
Text-mined interactions from Literome
Zhang et al., J Neurosci Res 2005
(Brain Infarction...) :
These studies reveal that the pattern of regulation of MCT1 expression after MCAO is similar to that observed previously for glucose transporter 1 (GLUT1) and suggest that the regulation of
MCT1 mRNA expression is
mediated by the hypoxia-inducible transcription factor
HIF1
Sonveaux et al., PloS one 2012
(Neoplasms...) :
Targeting the lactate transporter
MCT1 in endothelial cells
inhibits lactate induced
HIF-1 activation and tumor angiogenesis
Chiche et al., Ann Endocrinol (Paris) 2013
:
We reported that targeting these pHi regulated processes through inhibition of either
HIF-1 induced CAIX/CAXII or HIF-1 induced
MCT4 , MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis generated ATP levels and tumor growth