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IL2 — IRF6

Text-mined interactions from Literome

Schytte Blix et al., J Periodontal Res 1999 (Aggressive Periodontitis...) : We have studied the effect of lipopolysaccharide (LPS) extracted from these periodontopathogenic bacteria on synthesis of the proinflammatory cytokines, interleukin-1beta(IL-1beta) , tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) in human whole blood
Han et al., Gynecol Oncol 1999 (Ovarian Neoplasms) : IL-2 enhances standard IFNgamma/LPS activation of macrophage cytotoxicity to human ovarian carcinoma in vitro : a potential for adoptive cellular immunotherapy ... The objective was to evaluate the enhancement of human peritoneal macrophage cytotoxic in vitro activity by the addition of interleukin-2 (IL-2) to the standard interferon gama ( IFNgamma ) and lipopolysaccharide (LPS) activation procedure used for cellular adoptive immunotherapy in a human ovarian cancer system
Iwagaki et al., Infect Immun 2000 : The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Carroll et al., Am J Vet Res 2001 : Serum prolactin (PRL) concentration was decreased in pigs at 18 C, compared with pigs at 34 C. Challenge with LPS resulted in an increase in serum PRL concentration at 18 C but had no effect on serum PRL at 34 C. Challenge with LPS resulted in an increase in expression of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 receptor mRNA in the hypothalamus
Panerai et al., Diabetologia 2001 (Diabetes Mellitus, Type 1...) : Anti-CD3 and/or lipopolysaccharide (LPS) induced blood levels of interferon (IFN)-gamma, interleukin (IL)-4, IL-10, IL-12 and tumour necrosis factor (TNF)-alpha were measured by ELISA in 10 week-old female NOD mice treated for 6 consecutive weeks with either MFP14 or PBS
Zähringer et al., J Endotoxin Res 2001 : In human mononuclear cells ( hMNC ) the new LA ( tetra ) antagonized LPS induced release of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in a dose dependent manner with identical antagonistic potency as compared with compound 406
Nakajima et al., J Neurochem 2002 : C8-ceramide as well as LPS enhanced the production/secretion of BDNF but, different from LPS, did not induce tumor necrosis factor alpha, interleukin-1beta , or nitric oxide
Swinney et al., J Biol Chem 2002 : Ro106-9920 blocked lipopolysaccharide (LPS) dependent expression of TNFalpha, interleukin-1beta , and interleukin-6 in fresh human peripheral blood mononuclear cells with IC ( 50 ) values below 1 microm
Moré et al., Scand J Immunol 2002 : In contrast to the induction of IFN-gamma, antigen-specific IL-2 secretion and proliferation of T cells were rather decreased in the presence of LPS
Bonder et al., Cytokine 2002 : While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells
Armstrong et al., J Vet Pharmacol Ther 2002 : Production of the cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in response to lipopolysaccharide (LPS) , and the effects of addition of carprofen ( racemate and R and S enantiomers ) were determined
Lee et al., Biol Trace Elem Res 2002 : We measured the hydrogen peroxide and glutathione levels in cultured human T-lymphocytes and the proliferation of their subsets : T-helper/inducer, T-suppressor/cytotoxic, and natural killer and interleukin-2 receptors upon stimulation by the mitogens phytohemaglutinin ( PHA ) and lipopolysaccharide (LPS)
Aikawa et al., Inflamm Res 2002 (Leukemia, Monocytic, Acute) : T-614 inhibited LPS stimulated production of TNF-alpha, interleukin (IL)-6, and IL-8 in a concentration dependent manner with decreasing mRNA levels ( IL-6 and IL-8 )
Li et al., Acta Pharmacol Sin 2002 (Arthritis, Experimental) : To investigate the effects of leflunomide ( LEF ) on modulating interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) production induced by lipopolysaccharide (LPS) in peritoneal macrophages ( PMphi ) in adjuvant arthritis rats and elucidate the possible mechanisms of antiinflammatory and antirheumatoid effects of LEF
Zhu et al., J Leukoc Biol 2002 : With DC preparations obtained from murine bone marrow cultured in granulocyte macrophage-colony stimulating factor, the Ps ODN blocked the production of interleukin-12 and nitric oxide induced by bacterial DNA, an immunostimulatory cytosine phosphate guanosine dinucleotide ( CpG ) ODN and lipopolysaccharide (LPS)
Shinkai et al., Reproduction 2003 (Obstetric Labor, Premature...) : LPS induced premature delivery and an increase in prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ), interleukin 1alpha (IL-1alpha), IL-6 and IL-10 in the amniotic fluid, and an increase in IL-6 in plasma
Hinz et al., Biochem Biophys Res Commun 2003 (Inflammation) : Stimulation of cells with LPS resulted in a profound induction of the expression of COX-2, interleukin (IL)-1, IL-6, tumor necrosis factor (TNF), and granulocyte-macrophage colony stimulating factor ( GM-CSF )
Park et al., J Neurochem 2003 (Inflammation) : We observed that ( i ) chloroquine augmented LPS induced expression of pro-inflammatory cytokines such as lymphotoxin (LT)-beta, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta and IL-6 in human astroglial cells, while the same treatment suppressed LPS induced expression of cytokines in monocytic and microglial cells ; ( ii ) chloroquine alone induced expression of pro-inflammatory cytokines in a dose- and time dependent manner in astroglial cells ; ( iii ) other lysosomotropic agents such as ammonium chloride and bafilomycin A1 had minimal effects on cytokine expression ; and ( iv ) chloroquine induced the activation of nuclear factor-kappa B in astroglial cells, which is a required component of chloroquine induction of cytokines
Rudnicka et al., FEMS Immunol Med Microbiol 2003 (Chronic Disease...) : In this study, we assessed the proliferative response of peripheral blood mononuclear leukocytes ( PBML ) from 33 children/young adolescents with chronic dyspepsia, to H. pylori LPS in the presence and absence of IL-2 as a T cell growth factor
Kohut et al., J Am Coll Nutr 2003 : LPS induced production of IL-1beta, and PHA induced IL-2 , IL-4, IL-10, or IFN-gamma production was not altered by the supplement
Neate et al., Clin Exp Immunol 1992 : However, in the presence of LPS ( 1 microgram/ml ) CD4 expression was reduced to undetectable levels while the expression of IL-2R and MO3 was induced to maximal density ... Surface antigen expression after 7 days culture in medium supplemented with non-heat inactivated serum was essentially as seen after overnight culture, with the exception that LPS induced IL-2R expression was transient
Cui et al., Am J Physiol Regul Integr Comp Physiol 2004 (Shock) : In additional experiments, although 24-h infusions of LeTx and Escherichia coli LPS produced similar mortality rates ( 54 and 56 %, respectively ) and times to death ( 13.2 +/- 0.8 vs. 11.0 +/- 1.7 h, respectively ) compared with controls, only LPS reduced circulating leukocytes, platelets, and IL-2 levels and increased TNF-alpha, IL-1 alpha and -1 beta, IL-6, IL-10, interferon-gamma, granulocyte macrophage-colony stimulating factor, RANTES, migratory inhibitory protein-1 alpha, -2, and -3, and monocyte chemotactic protein-1, as well as nitrate/nitrite levels ( all P < or = 0.05 for the effects of LPS )
Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Shin et al., J Ethnopharmacol 2004 (Fatigue Syndrome, Chronic) : KBT ( 1 mg/ml ) significantly inhibited LPS induced tumor necrosis factor-alpha, interleukin-10 , and transforming growth factor-beta1 production in PBMC of CFS patients
Szuster-Ciesielska et al., Arch Immunol Ther Exp (Warsz) 2004 : In the same in vitro conditions they inhibited PHA+LPS stimulated production of IL-2 and lymphotoxin
Fiebich et al., Phytomedicine 2004 : The Salix extract inhibited the LPS induced release of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 with IC50-values of 180.0, 33.0 and 86.0 microg/ml, respectively
Shin et al., FEBS Lett 2004 (Inflammation) : Furthermore, the compound inhibited not only LPS induced expressions of tumor necrosis factor-alpha, interleukin (IL)-1beta , IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS induced apoptosis of the RAW 264.7 cells
Arai et al., J Biol Chem 2004 : Our results indicate that the neurotoxic effects of LPS on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta , and caspase-11 expression in mice
Paintlia et al., J Neurosci Res 2004 (Demyelinating Diseases...) : Intraperitoneal pretreatment of pregnant female rats with NAC ( 50 mg/kg ), 2 hr prior to administration of LPS at embryonic day 18 ( E18 ), attenuated the LPS induced expression of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta , and inducible nitric oxide synthase in fetal rat brains
Newport et al., Tuberculosis (Edinb) 2004 (Genetic Predisposition to Disease...) : LPS induced tumour necrosis factor, interleukin-1 beta and interleukin-10 production was not influenced by TLR4 Asp299Gly genotype
Labuzek et al., Eur Neuropsychopharmacol 2005 : Quinpirole-a D2 dopaminergic agonist increased LPS induced IL-1beta and IL-2 secretion in mixed glia cultures only in the highest dose of 20 microM
Pandey et al., Int Immunopharmacol 2005 : B. diffusa hexane, chloroform and ethanol extracts, and two pure compounds Bd-I ( eupalitin-3-O-beta-D-galactopyranoside ) and Bd-II ( eupalitin ) were evaluated in vitro for their effect on T cell mitogen ( phytohemagglutinin ; PHA ) stimulated proliferation of human peripheral blood mononuclear cell ( PBMC ), mixed lymphocyte culture, lipopolysaccharide (LPS) stimulated nitric oxide production by RAW 264.7, PHA and LPS induced IL-2 and TNF-alpha production, in human PBMCs, superoxide production in neutrophils, human natural killer ( NK ) cell cytotoxicity and nuclear translocation of nuclear factor- ( kappa ) B and AP-1 in PHA stimulated PBMCs
Chien et al., Chin J Physiol 2004 : Our results indicated that ( 1 ) LPS stimulated pHi elevation was PKC dependent ; ( 2 ) After 30 min stimulation, LPS increased PLD activity via a measured production of 3H-phosphatidylethanol from phosphatidic acid and the initiation of PLD1a mRNA expression started ; ( 2 ) LPS stimulated IL-2 R expression but not IL-2 and IL-4 secretion
Thirunavukkarasu et al., J Cell Physiol 2005 : LPS stimulated the synthesis of TNF-alpha, interleukin (IL)-6, and IL-1beta but not of TGF-beta in qHSCs
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40, interleukin (IL)-6 , monocyte chemotactic protein (MCP)-1, cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Schartz et al., Eur J Immunol 2005 : Lipopolysaccharide (LPS) stimulation of mouse bone marrow derived DC results in early IL-2 production unless IL-4 is introduced in DC cultures
Francey et al., Vet Immunol Immunopathol 1992 : LPS triggering promoted the secretion of interleukin-1 , as evidenced by measurement of murine thymocyte costimulatory activity, and transforming growth factor-beta
Kim et al., Antioxid Redox Signal 2005 (Inflammation) : The LPS induced expression of inducible proinflammatory genes such as inducible NO synthase, interleukin (IL)-1beta , IL-6, and granulocyte-macrophage colony stimulating factor was significantly abolished ( IRs=99.1 %, 74.6 %, 74.0 %, and 64.4 %, respectively ) by aframodial
Suzuki et al., Biomed Pharmacother 2006 : Using enzyme linked immunosorbent assays ( ELISAs ) we showed DHMEQ to inhibit LPS induced secretion of IL-6, IL-12, interleukin-1beta (IL-1beta), and TNF-alpha
Inoue et al., J Appl Toxicol 2007 : LPS significantly increased the protein levels of IFN-gamma, IL-2 and IL-10
Baba et al., Gen Physiol Biophys 2006 : However, aziridine 2 had no effect on the resting lymphocyte proliferation in the absence of mitogens, at any concentration used, reduced Con A-stimulated T lymphocyte proliferation and LPS- stimulated B lymphocyte proliferation in a dose dependent manner and diminished IL-2 and IL-6 production
Tyagi et al., Life Sci 2007 (Dementia...) : LPS significantly increased the level of IL-2 in all the brain areas while enhancement of AChE activity varied in brain areas ... It was found that administration of tacrine, rivastigmine and donepezil in mice significantly attenuated the LPS induced increased levels of IL-2 along with the significant reduction of AChE activity predominantly in salt soluble ( SS ) fraction as compared to the detergent soluble ( DS ) fraction in a dose dependent manner
Hadley et al., Shock 2007 (Inflammation) : At the end of CPB, ex vivo production of tumor necrosis factor alpha, interleukin (IL) 1beta, IL-8, and IL-10 in response to PepG or LPS was virtually abolished ( P < 0.05 )
Sakata et al., Immunology 2007 (Disease Models, Animal...) : We report here the effects of the most potent SMase inhibitor, SMA-7, on the LPS mediated release of tumour necrosis factor-alpha, interleukin-1beta and interleukin-6 from THP-1 macrophages and the pathology of dextran sulphate sodium (DSS) induced colitis in mice
Shui et al., Rheumatology (Oxford) 2007 (Disease Models, Animal...) : First, it is not known whether LPS can stimulate mesangial cells (MCs) to secrete the pro-inflammatory cytokine, interleukin (IL)-18
Boos et al., Am J Cardiol 2007 (Atrial Fibrillation...) : Effects of LPS on high-sensitivity C-reactive protein, interleukin-6 , tumor necrosis factor-alpha, and neutrophil counts as indexes of an inflammatory response were also assessed ... LPS led to overall marked increases in high-sensitivity C-reactive protein, interleukin-6 , tumor necrosis factor-alpha, and neutrophil counts ( all p < 0.0001 ) and an average temperature increase of 1.1 degrees C
Kim et al., Arch Pharm Res 2007 (Periodontitis) : LPS enhanced ROS production, as well as, expression of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6 , interleukin-8 and tumor necrosis factor-alpha, and the production and activation of MMP2
Santander et al., Biomedica 2007 (Chagas Disease) : KMP-1 1 protein does not affect the maturation of dendritic cells, but in the presence of LPS the K1 peptide leads to a decreased expression of CD86 and CD83 as well as interleukin-12 production, This phenomenon may be associated with an impaired T cell stimulation
Hughes et al., Circ Res 2008 (Inflammation) : Pretreatment of macrophages with 500 nmol/L S1P markedly reduced LPS mediated secretion of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and interleukin-12
Motoyoshi et al., Neurochem Int 2008 (Gliosis...) : Both AmB and LPS also induced mRNA expressions of interleukin-1beta, interleukin-6 , and tumor necrosis factor-alpha in microglia
Chochi et al., Clin Cancer Res 2008 (Helicobacter Infections...) : H. pylori LPS induced neither interleukin-12 nor IFN-gamma production by MNC, although E. coli LPS did induce production of both significantly
Hollenbach et al., Biochem Pharmacol 2008 : In contrast, both EP and EL were shown to suppress the Lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-8 from human immunocompetent cells, and modulated the expression of the immune receptors HLA-DR, CD14 and CD91 on human monocytes
Reikeras et al., J Trauma 2009 (Hip Injuries) : Ex vivo lipopolysaccharide (LPS) and peptidoglycan ( PepG ) induced tumor necrosis factor-alpha (TNF-alpha) and interleukin ( IL-10 ) releases were measured in whole blood sampled preoperatively and added serum taken before, at the end of operation and at postoperative day 1 and 6
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009 : LPS induced secretion of prostaglandin E2 ( PGE2 ), interleukin (IL)-6 , and keratinocyte derived chemokines ( KC ) was measured by ELISA
Avni et al., Immunol Lett 2009 (Inflammation) : In this study we thus investigated the effect of PCERA-1 on LPS induced release of TNFalpha, interleukin (IL)-10 and IL-12p40, in vivo, and ex vivo
Zemans et al., Cell Immunol 2009 : Furthermore, LPS induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha, interleukin-6 , and interleukin-1beta expression are dependent on Tec kinase activity
Suo et al., J Ethnopharmacol 2009 : Moreover, the effects of MT on soluble intercellular adhesion molecule-1 ( sICAM-1 ), interleukin-6 (IL-6) and interleukin-8 (IL-8) production induced by lipopolysaccharide (LPS) in these cells were evaluated
Novem et al., Clinical and vaccine immunology : CVI 2009 : In this study, the biological activities of B. pseudomallei LPS were compared to those of Burkholderia thailandensis LPS, and it was found that both murine and human macrophages produced levels of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 in response to B. pseudomallei LPS that were lower than those in response to B. thailandensis LPS in vitro
Asghar et al., American journal of physiology. Renal physiology 2009 (Hypertension...) : We found that LPS increased the levels of inflammatory cytokines, interleukin-6 , and tumor necrosis factor-alpha in the rats given either normal- or high-salt intake
Inaba et al., J Nat Med 2010 (Arthritis, Experimental) : HP-ext dose-dependently suppressed the lipopolysaccharide (LPS) induced production of inflammatory cytokines [interleukin-1beta ( IL-1beta ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) ] in mouse macrophage cells ( RAW 264.7 )
Negishi et al., Am J Reprod Immunol 2011 : ( ii ) TNF-a was also induced by LPS but was not affected by the presence of IL-2 and IL-12
Villalonga et al., Biochem Pharmacol 2010 (Arthritis, Rheumatoid) : LPS induced macrophage migration and IL-2 production in stimulated Jurkat T-cells were also blocked by pharmacological doses of diclofenac
Pan et al., Cell Physiol Biochem 2010 (Inflammation) : NFkappaB not only mediated the LPS induced increase of MDR1b, IL2Rgamma , and TNFR2 mRNA in the wildtype mice, but it showed opposite effects by elevating IL15Ralpha and TNFR1 mRNA and decreasing IL2Ralpha in the knockout mice
Cheng et al., J Ethnopharmacol 2010 : Treatment with BPs enhanced phagocytic functions of macrophages ( phagocytosis of apoptotic thymocytes, IgG opsonized sheep red blood cells and chicken red blood cells ) and inhibited LPS induced productions of NO and proinflammatory cytokines ( interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha )
Yu et al., Phytother Res 2011 (Inflammation) : PA significantly inhibited the LPS induced production of nitric oxide ( NO ), interleukin-1ß (IL-1ß) and tumor necrosis factor-a (TNF-a)
Bagnasco et al., J Endocrinol Invest 1990 : The following variables were evaluated : T cell proliferation following stimulation with phytohemagglutinin ( PHA ), and anti-CD3 or anti-CD2 monoclonal antibodies ; interleukin-2 (IL-2) and gamma-interferon ( gamma-IFN ) production by PHA stimulated T cells in bulk culture and by T cell clones ; PHA induced IL-2 receptor expression ; LPS induced interleukin-1 production by accessory cells
Xin et al., Cell Biochem Funct 2011 : To determine if microglial cells, a subset of glial cells, are involved in asymmetric production, interleukin-6 (IL-6), interleukin-1ß (IL-1ß) and nitric oxide ( NO ) responses to LPS by microglial cells in the right and left cerebral cortices were examined
Tavano et al., J Innate Immun 2011 : Suboptimal stimulatory doses ( 5-10 µM ) of apidaecin partially inhibited the lipopolysaccharide (LPS) induced increase in major histocompatibility complex class II ( MHCII ) and CD86 in macrophages, and the release of selected cytokines/chemokines by both macrophages [ interleukin (IL)-6 and tumor necrosis factor (TNF)-a ] and monocytes [IL-6, TNF-a, basic fibroblast growth factor (FGF) and eotaxin ]
Liu et al., Neurol Res 2011 : Both the LPS and amyloid-beta peptide enhanced interleukin 1, interleukin 6, and tumor necrosis factor-alpha synthesis and these effects were inhibited by 10 ( -9 ) M coumestrol
Choi et al., Biol Pharm Bull 2011 : Cornuside significantly inhibited the LPS induced production of nitric oxide, prostaglandin E ( 2 ), tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta
Hung et al., Am J Chin Med 2011 (Drug-Induced Liver Injury...) : Our results showed that ES reduced LPS induced nitric oxide ( NO ), interleukin (IL)-1 , IL-6, reactive oxygen species ( ROS ), and prostaglandin ( PGE ( 2 ) ) production in BV-2 cells
Uto et al., Int Immunopharmacol 2012 : Among these jolkinolides, 17-hydroxy-jolkinolide B ( HJB ) exhibited the most potent inhibition of LPS induced production of inflammatory mediators such as prostaglandin E ( 2 ) ( PGE ( 2 ) ), nitric oxide ( NO ), and pro-inflammatory cytokines [ interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) ]
Yu et al., Inflammation 2012 (Inflammation) : Pyranocoumarins significantly inhibited LPS induced production of nitric oxide, interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a)
Zhu et al., Zhong Xi Yi Jie He Za Zhi 1990 : When the drug was added from 0.6 mg/ml to 5 mg/ml a significant dose dependent inhibition effect was shown in the following immune reactions of mice ( P less than 0.05-0.01 ) : phagocytic function of peripheral blood leucocytes assayed by chemiluminescence ; mitogenic response of spleen lymphocytes to Con A ; mixed lymphocyte culture and LPS induced interleukin-1 release of macrophages
Zhang et al., Phytochemistry 2012 : E. paradoxa var. paradoxa, rich in polyenes/polyacetylenes, was an especially efficient inhibitor of LPS induced production of nitric oxide ( NO ), prostaglandin E2 ( PGE2 ), interleukin-1 beta ( IL-1ß ) and interleukin-6 (IL-6) by 46 %, 32 %, 53 % and 26 %, respectively, when tested at 20 µg/ml in comparison to DMSO control
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Zhu et al., PloS one 2012 : Our results show that artemisinin significantly inhibited LPS induced production of tumor necrosis factor-alpha ( TNF-a ), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide ( NO )
Reyes et al., Eur J Nutr 2013 (Inflammation) : Calcium induced thromboxane B ( 2 ) and nitric oxide production, LPS induced prostaglandin E ( 2 ) and nitric oxide production and LPS induced interleukin 1ß production were measured
Holen et al., Fish Shellfish Immunol 2012 : LPS cell activation increased mRNA expression of interleukin 8 ; interleukin-1ß ; cyclooxygenase 2 ; leukocyte derived chemotaxin 2 ; carboxyl-esterase 2 and environmental biomarker cytochrome P450 1A
Hebeda et al., Arch Toxicol 2012 : Hydroquinone treatment impaired LPS induced nitric oxide ( NO ), tumour necrosis factor a (TNF-a), interleukin (IL)-1ß and IL-6 secretions by neutrophils
Rajan et al., Spine (Phila Pa 1976) 2013 : LPS stimulation resulted in significant increases in tumor necrosis factor a (TNF)-a, interleukin (IL)-1ß, IL-6, and nitric oxide levels and significant inhibition in aggrecan and collagen-2
Sulyok et al., Br J Anaesth 2012 (Colorectal Neoplasms...) : The following parameters were measured : lipopolysaccharide (LPS) induced tumour necrosis factor (TNF)-a, procalcitonin ( PCT ), interleukin (IL)-6/10, heat shock proteins ( HSPs ) 60, 70, and 90, human leucocyte antigen-DR ( HLA-DR ), and LPS binding protein (LBP)
Hsiao et al., PloS one 2012 (Acute Disease...) : In addition, the LNA and MNA groups had significantly decreased spontaneous IL-6 and Con A-stimulated TNF-a and IFN-? production by the leukocytes while the HNA group had significantly increased LPS stimulated TNF-a and Con A-stimulated IFN-? and IL-2 production by the splenocytes compared to the CPP group
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Zhang et al., Bioorg Med Chem 2012 : The lead compound 1 ( NCI126224 ) was found to suppress LPS induced production of nuclear factor-kappaB ( NF-?B ), tumor necrosis factor ( TNF-a ), interleukin-1ß (IL-1ß), and nitric oxide ( NO ) in the nanomolar-low micromolar range
Jung et al., Arterioscler Thromb Vasc Biol 2012 : Eicosapentaenoic acid alone or with LPS blunted LPS mediated stimulation of macrophage proinflammatory interleukin-6, interleukin-12p40 , and toll-like receptor-4 mRNA and increased anti-inflammatory interleukin-10 and mannose receptor mRNA
Hsiang et al., Food Chem 2013 (Inflammation) : In vivo and ex vivo imaging showed that LPS increased NF-?B luminescence in the abdominal region, which was significantly inhibited by TS or GA. Immunohistochemical and ELISA analyses confirmed that TS and GA inhibited LPS induced NF-?B, interleukin-1ß , and tumour necrosis factor-a expression
Cheng et al., J Sci Food Agric 2013 (Inflammation) : PV inhibited LPS stimulated nitric oxide ( NO ), prostaglandin ( PG ) E ( 2 ), interleukin (IL)-1ß and tumour necrosis factor (TNF)-a release and inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 protein expression
Ruchelman et al., Bioorg Med Chem Lett 2013 : The 4-methyl and 4-chloro analogs 4 and 15, respectively, displayed potent inhibition of tumor necrosis factor-a (TNF-a) in LPS stimulated hPBMC, potent stimulation of IL-2 in a human T cell co-stimulation assay, and anti-proliferative activity against the Namalwa lymphoma cell line
Ro et al., Transplantation 2012 : Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-?-inducible protein-10, monocyte chemotactic protein-1, interleukin-8 , and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-ß promoter stimulator-1-KO, and TLR4-KO mice
Kitagawa et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : In the experiment using isolated Kupffer cells, the expression of interleukin-6, interleukin-1ß , and endothelin-1 in response to LPS stimulation was attenuated by BCAA in a dose dependent fashion
Zhu et al., Biol Pharm Bull 2013 (MAP Kinase Signaling System) : Mollugin attenuated the LPS induced expression of nitric oxide ( NO ), inducible nitric oxide synthase (iNOS), interleukin (IL)-1ß and IL-6 but augmented the expression of tumor necrosis factor (TNF)-a
Chen et al., Food Chem Toxicol 2013 (Inflammation) : Both water and ethanolic extracts of I. suffruticosa significantly decreased LPS induced nitric oxide ( NO ) as well as the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-a, and pro-interleukin-1ß
Song et al., Eur J Pharmacol 2013 (Sepsis) : In RAW264.7 and mouse peritoneal macrophages, bis-N-norgliovictin dose-dependently inhibited LPS induced production of TNF-a, interleukin-6 (IL-6), interferon-ß ( IFN-ß ) and monocyte chemoattractant protein ( MCP-1 ), but without suppressing cell viability
Kang et al., Environ Toxicol Pharmacol 2013 (Inflammation) : It was demonstrated that LPS can induce the production of pro-inflammatory cytokines such as interleukin-1ß (IL-1ß), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a) as well as the expression of inflammatory mediators as cyclooxygenase-2 (COX-2), and inducible nitric oxide synthases (iNOS) from HepG2 cells
Li et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013 : To observe the expression of progesterone receptor (PR), interleukin-1ß (IL-1ß), and cyclooxygenase-2 (COX-2) induced by lipopolysaccharide (LPS) or Toll-like receptor 4 antagonist ( TLR4 mAb ) in decidual cells in vitro, and then to explore the effect of LPS and its antagonist on PR of decidual cells and the relation between PR and inflammatory cytokines
Hu et al., Int J Mol Med 2013 : We found that GLGZD inhibited the inflammatory response in microglial cells as it significantly reduced LPS induced expression of pro-inflammatory nitric oxide, tumour necrosis factor-a, interleukin (IL)-6 and IL-1ß in BV-2 cells, in a dose dependent manner
Li et al., Mol Med Report 2013 (Acute Lung Injury...) : The upregulation of matrix metalloproteinase-9, interleukin (IL)-1ß , IL-6 and inducible nitric oxide synthase was induced by LPS in the mouse model of sepsis and the TC-1 cell line, and resveratrol suppressed the overexpression of these proinflammatory molecules in a dose-dependent manner
Olajide et al., Evidence-based complementary and alternative medicine : eCAM 2013 : Our results showed that cryptolepine significantly inhibited LPS induced production of tumour necrosis factor-alpha ( TNF a ), interleukin-6 (IL-6), interleukin-1beta ( IL-1 ß ), nitric oxide, and PGE2
Li et al., Eur J Pharmacol 2013 : Our data demonstrated that THC significantly inhibited LPS induced TNF-a, interleukin-6(IL-6) and nitric oxide ( NO ) production
Shin et al., Neurosci Lett 2013 (Inflammation) : NK-4 inhibited LPS induced upregulation of inducible NO synthase (iNOS), cyclooxygenase-2, interleukin-6, tumor necrosis factor-a, and interleukin-1ß in RAW264.7 cells in a time- and concentration dependent manner
Wu et al., Immunopharmacol Immunotoxicol 2013 : Materials and methods : We evaluated the effect of TBMS1 on LPS induced production of tumor necrosis factor (TNF)-a, interleukin (IL)-6 and IL-1ß in the culture supernatants of RAW 264.7 cells by enzyme linked immunosorbent assay
Sung et al., Biochem Biophys Res Commun 2013 : We also found that Pro B2-treated macrophages inactivated naïve T cells by inhibiting LPS induced interferon-? and IL-2 secretion through IRAK-M
Cavaillon et al., Cell Immunol 1987 : Inhibition by gangliosides of the specific binding of lipopolysaccharide (LPS) to human monocytes prevents LPS induced interleukin-1 production
Sultzer et al., Infect Immun 1988 : DNA synthesis, polyclonal antibody synthesis, and interleukin-1 activity were stimulated by Bordetella pertussis LPS and Salmonella minnesota R595 LPS, although to a lesser extent than with responder cells
Ernst et al., J Clin Immunol 1986 (Acquired Immunodeficiency Syndrome) : In particular, we found a transient increase in C3b receptor mediated monocyte activation in ARC patients ; no influence of therapy on the otherwise intact LPS induced interleukin-1 production in vitro ; in some patients a transient corrective influence on the high pretherapeutic immunoglobulin secretion of B cells and their nonresponsiveness to pokeweed mitogen ; low T-cell responses to soluble antigens and alloantigens, which were partially restored during rIL-2 treatment in ARC patients and in one AIDS patient ; defective NK activity in PBMC of two AIDS patients, which was found to be restored when measured at the end of rIL-2 therapy ; and a rather constant phenotypic pattern of PBMC in each patient during therapy except for the decreasing proportion of OKT9 positive lymphocytes in AIDS patients, the increasing proportion of Leu8-Leu3a+ lymphocytes in all patients, and in particular, the transient significant decrease in the Leu7+/OKT3+ ratio, which pretherapeutically was very high in AIDS patients ( 0.78 +/- 0.21 ) and high in ARC patients ( 0.48 +/- 0.06 ) as compared to healthy controls ( 0.18 +/- 0.08 )
Cavaillon et al., Mol Immunol 1986 : Polymyxin-B inhibition of LPS induced interleukin-1 secretion by human monocytes is dependent upon the LPS origin
Billiar et al., Ann Surg 1988 : When cultured alone, Kupffer cells from these animals also produced more interleukin-1 ( p less than 0.002 ) and prostaglandin E2 ( PGE2 ) ( p less than 0.009 ) in response to LPS
Fujiwara et al., J Gen Microbiol 1988 : These LPS also enhanced interleukin-1 production by murine peritoneal macrophages and mouse cell line J744
Warren et al., Infect Immun 1988 : These data suggest that there may exist a self regulated mechanism for decreasing the toxicity of LPS and the production of LPS induced interleukin-1 ; this mechanism is controlled by a macrophage factor and functions through altering the binding of LPS to certain serum lipoproteins
Mitchell et al., Immunology 1986 (Disease Susceptibility...) : In vitro production of interleukin-1 (IL-1) by LPS stimulated adherent peritoneal exudate and spleen cells and alveolar macrophages, and interleukin-2 (IL-2) by concanavalin A-stimulated splenocytes were measured in resistant ( C57BL/6J ) and susceptible ( A/J ) inbred mice during the early stages of subacute infections with the African trypanosome, Trypanosoma congolense
Gallily et al., Cancer Immunol Immunother 1986 (Neoplasms, Experimental) : However, LPS induced interleukin 1 release was partially ( 55 % ) suppressed by embryonic fibroblast culture supernatant
Nitta et al., Immunology 1986 : These results suggest that the synergistic effect of Con A and LPS or Bu-WSA on the proliferative response of HC-treated thymic cells is mainly due to the enhanced production of IL-2 and its action to increase cell growth, and there are two pathways by which the enhancement of IL-2 production by Con A and LPS or Bu-WSA can occur : an IL-1 dependent pathway, or an IL-1 independent one
Gasbarre et al., Vet Immunol Immunopathol 1984 : Porcine IL2 production by pig lymphocytes was induced by the mitogens Concanavalin A ( Con A ) Phytohemagglutiniin ( PHA ), and Pokeweed mitogen ( PWM ), but not by lipopolysaccharide (LPS)
Pure et al., J Immunol 1982 : Similarly, IL 2 had no effect on LPS or BCDF gamma induced IgG secretion by normal B cells
Lundgren et al., Eur J Immunol 1995 : Smu-S gamma 1 switch recombination in lipopolysaccharide (LPS) + interleukin-4 (IL-4) activated mouse B cells was assayed by a digestion-circularization polymerase chain reaction
Fahmi et al., Cell Immunol 1993 : To achieve a better understanding of the mechanism of this type of desensitization, we studied the regulation of the production of interleukin 1, interleukin 6, and tumor necrosis factor alpha by mouse peritoneal macrophages in response to LPS , after a preliminary exposure to LPS or to structurally related synthetic lipids
Koga et al., Biosci Biotechnol Biochem 1993 : SP-MAF1 also increased splenocyte proliferation that was induced by LPS and ConA, and ConA induced production of IL-2 by splenocytes
Daniel et al., Vet Immunol Immunopathol 1993 : While resting cells produced no detectable interleukin 1, stimulation with lipopolysaccharide (LPS) induced the production of biologically active interleukin 1
Sugiyama et al., Infect Immun 1996 : In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect
Janz et al., Physiol Behav 1996 : The present study used a taste aversion paradigm to condition lipopolysaccharide (LPS) induced suppression of splenic lymphocyte interleukin-2 (IL-2) production, with concurrent measurement of corticosterone production and splenic norepinephrine ( NE ) content )
El-Mohandes et al., Biol Neonate 1995 : LPS stimulation of CBM induced IL-2R expression and enhanced HLA-DR antigen expression as seen previously on PBM
Persoons et al., Am J Respir Cell Mol Biol 1996 : When alveolar macrophages were cultured, substantial amounts of interleukin-1(IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF-alpha), and nitric oxide are produced upon stimulation with LPS
Suttles et al., J Leukoc Biol 1996 : Recent studies have demonstrated that monocytes can be rescued from apoptosis via lipopolysaccharide (LPS) activation or stimulation with interleukin-1 or tumor necrosis factor-alpha
Yang et al., Scand J Immunol 1997 : In the present study, the authors investigated the combined effects of avirulent Semliki Forest virus ( SFV-A7 ) and bacterial lipopolysaccharide (LPS) on the interleukin-1 beta (IL-1 beta) and IL-2 gene expression in murine splenic cells
West et al., Ann Surg 1997 : Macrophages incubated in CO2 produced significantly less TNF and interleukin-1 in response to LPS compared to incubation in air or helium
Alford et al., Biochem Biophys Res Commun 1997 : The macrophage-colony stimulating factor receptor, c-fms, is induced by IL-2 in monocytes and is suppressed by LPS , LPS plus IFN-gamma, phorbol esters, and colony stimulating factor in monocytes/macrophages
Weng et al., Int Immunol 1997 : The first pattern, characterized by the responses of all T cells, HLA-DRlo cells, monocytes, IL-2R+ cells, IFN-gamma, and augmented lymphocyte mitotic responses to lipopolysaccharide (LPS) and SEB in culture, was a rapid increase at 20 min followed by a quick decrease at 90 min to approximately the original levels
Sastre et al., Biochem J 1998 : In the present study we sought to determine : ( a ) whether macrophages ( cell line RAW 264.7 ) express ADC and agmatinase, and ( b ) if the enzymes are regulated by lipopolysaccharide (LPS) , and/or by the inhibitory cytokines transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-4 (IL-4)
Ju et al., Pharmacology 1998 (Disease Models, Animal...) : In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in mice
Mynster et al., Vox Sang 1998 : IL-2 was not detected in response to LPS stimulation
Amura et al., Infect Immun 1998 (Sepsis) : These cells manifested markedly enhanced levels of in vitro TNF-alpha, interleukin 6 (IL-6), and nitric oxide production in response to LPS