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ERBB3 — PI3

Text-mined interactions from Literome

Schoeberl et al., Cancer Res 2010 (Neoplasms) : ErbB3 is a critical activator of phosphoinositide 3-kinase (PI3K) signaling in epidermal growth factor receptor ( EGFR ; ErbB1 ), ErbB2 [ human epidermal growth factor receptor 2 ( HER2 ) ], and [ hepatocyte growth factor receptor ( MET ) ] addicted cancers, and reactivation of ErbB3 is a prominent method for cancers to become resistant to ErbB inhibitors
Smirnova et al., Oncogene 2012 (Breast Neoplasms...) : We tested the hypothesis that ErbB3 mediated PI3-kinase signaling is critical for heregulin induced motility, and therefore crucial for ErbB3 mediated invasion, intravasation and metastasis
Carver et al., Endocrinology 1997 : The PI-3 kinase inhibitors, wortmannin and LY294002, completely blocked the inhibition of ErbB3 protein expression by insulin, suggesting a role for PI-3 kinase in the regulation of this growth factor receptor